Profile change history
A deterministic history of records added to PeptideScanner and preserved profile or record revisions connected through the reviewed Setmelanotide identity.
Source-published notices
Crossref dates: February 1, 2023. Checked August 19, 2026. The metadata identifies a connected notice but does not describe its scientific impact.
Before and after
We rewrote the profile summary to describe the cited public record more directly. The cited sources and status did not change.
Collection chronology
Showing the latest 64 additions by PeptideScanner publication date; the complete connected record set remains available in Latest Research. Most recent addition: August 22, 2026.
DailyMed lists Structured Product Labeling version 1 for the reviewed Setmelanotide label family with a published date of 2020-12-16. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.
DailyMed lists Structured Product Labeling version 12 for the reviewed Setmelanotide label family with a published date of 2025-09-05. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.
DailyMed lists Structured Product Labeling version 13 for the reviewed Setmelanotide label family with a published date of 2025-12-22. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.
DailyMed lists Structured Product Labeling version 14 for the reviewed Setmelanotide label family with a published date of 2026-04-02. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.
DailyMed lists Structured Product Labeling version 3 for the reviewed Setmelanotide label family with a published date of 2022-04-12. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.
DailyMed lists Structured Product Labeling version 4 for the reviewed Setmelanotide label family with a published date of 2022-04-27. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.
DailyMed lists Structured Product Labeling version 5 for the reviewed Setmelanotide label family with a published date of 2022-07-04. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.
DailyMed lists Structured Product Labeling version 6 for the reviewed Setmelanotide label family with a published date of 2023-11-29. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.
DailyMed lists Structured Product Labeling version 8 for the reviewed Setmelanotide label family with a published date of 2025-05-19. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.
DailyMed lists Structured Product Labeling version 9 for the reviewed Setmelanotide label family with a published date of 2025-05-23. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.
The Federal Register published notice 2020-27760, attributed to FDA and its parent HHS department, on 2020-12-17. Its official title is “Issuance of Priority Review Voucher; Rare Pediatric Disease Product,” and PeptideScanner's exact reviewed identity mapping connects the document to Setmelanotide.
The Federal Register published notice 2022-14134, attributed to FDA and its parent HHS department, on 2022-07-01. Its official title is “Determination of Regulatory Review Period for Purposes of Patent Extension; IMCIVREE,” and PeptideScanner's exact reviewed identity mapping connects the document to Setmelanotide.
The Federal Register published notice 2022-16502, attributed to FDA and its parent HHS department, on 2022-08-03. Its official title is “Product-Specific Guidances; Draft and Revised Draft Guidances for Industry; Availability,” and PeptideScanner's exact reviewed identity mapping connects the document to Setmelanotide.
The Federal Register published rule 2026-07863, attributed to FDA and its parent HHS department, on 2026-04-22. Its official title is “Medical Devices; Clinical Chemistry and Clinical Toxicology Devices; Classification of the Setmelanotide Eligibility Gene Variant Detection System,” and PeptideScanner's exact reviewed identity mapping connects the document to Setmelanotide.
PeptideScanner retained ClinicalTrials.gov record NCT05093634 at 2026-08-13T05:52:27.024Z. Its registry update date was 2026-08-06, and PeptideScanner's reviewed identity mapping was setmelanotide.
PeptideScanner retained ClinicalTrials.gov record NCT07496463 at 2026-08-10T18:10:04.219Z. Its registry update date was 2026-07-23, and PeptideScanner's reviewed identity mapping was setmelanotide.
The official Drugs@FDA dataset lists original submission 1 for NDA 213793 with status AP dated 2020-11-25, and names setmelanotide acetate among the application record's active ingredients.
PeptideScanner retained ClinicalTrials.gov record NCT06596135 at 2026-08-10T18:10:03.859Z. Its registry update date was 2026-07-15, and PeptideScanner's reviewed identity mapping was setmelanotide.
PubMed lists PMID 27339818 in British journal of pharmacology as Journal Article, with publication-date metadata of 2016-07-27 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.
PubMed lists PMID 29031731 in Molecular metabolism as Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2017-07-08 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.
PubMed lists PMID 33137294 in The lancet. Diabetes & endocrinology as Journal Article, Comment, with publication-date metadata of 2020-10-30 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.
PubMed lists PMID 33638809 in Drugs as Journal Article, Review, with publication-date metadata of 2021-02 (month precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.
PubMed lists PMID 33787829 in American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists as Journal Article, with publication-date metadata of 2021-03-31 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.
PubMed lists PMID 34544109 in The Medical letter on drugs and therapeutics as Journal Article, Review, with publication-date metadata of 2021-07-26 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.
PubMed lists PMID 35931197 in Life sciences as Journal Article, with publication-date metadata of 2022-08-02 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.
PubMed lists PMID 38697183 in The lancet. Diabetes & endocrinology as Journal Article, Comment, with publication-date metadata of 2024-04-30 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.
PubMed lists PMID 38697184 in The lancet. Diabetes & endocrinology as Journal Article, Clinical Trial, Phase II, Multicenter Study, Research Support, Non-U.S. Gov't, with publication-date metadata of 2024-04-30 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.
PubMed lists PMID 39394922 in Journal of peptide science : an official publication of the European Peptide Society as Journal Article, with publication-date metadata of 2024-10-12 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.
PubMed lists PMID 39526054 in TouchREVIEWS in endocrinology as Journal Article, Review, with publication-date metadata of 2024-02-09 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.
PubMed lists PMID 39549717 in The lancet. Diabetes & endocrinology as Journal Article, with publication-date metadata of 2024-11-13 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.
PubMed lists PMID 40484968 in Orphanet journal of rare diseases as Journal Article, with publication-date metadata of 2025-06-08 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.
PubMed lists PMID 40836563 in Journal of clinical research in pediatric endocrinology as Journal Article, with publication-date metadata of 2025-08-21 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.
PeptideScanner retained PubMed bibliographic metadata for PMID 33137293 at 2026-07-30T16:20:34.542Z. PubMed recorded a metadata revision date of 2026-05-18 and an Entrez history date of 2020-11-02. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained PubMed bibliographic metadata for PMID 34561620 at 2026-07-30T16:14:06.776Z. PubMed recorded a metadata revision date of 2026-06-08 and an Entrez history date of 2021-09-25. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained PubMed bibliographic metadata for PMID 38567654 at 2026-08-10T18:13:32.350Z. PubMed recorded a metadata revision date of 2026-07-04 and an Entrez history date of 2024-04-03. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained PubMed bibliographic metadata for PMID 38987029 at 2026-07-30T16:22:12.162Z. PubMed recorded a metadata revision date of 2026-04-17 and an Entrez history date of 2024-07-10. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained PubMed bibliographic metadata for PMID 39284294 at 2026-07-30T16:22:15.952Z. PubMed recorded a metadata revision date of 2026-04-17 and an Entrez history date of 2024-09-16. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained PubMed bibliographic metadata for PMID 40903014 at 2026-07-30T16:25:12.584Z. PubMed recorded a metadata revision date of 2026-02-19 and an Entrez history date of 2025-09-03. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained PubMed bibliographic metadata for PMID 41401696 at 2026-07-30T16:22:18.312Z. PubMed recorded a metadata revision date of 2026-04-17 and an Entrez history date of 2025-12-16. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained PubMed bibliographic metadata for PMID 41601974 at 2026-07-30T16:31:25.541Z. PubMed recorded a metadata revision date of 2026-01-31 and an Entrez history date of 2026-01-28. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained PubMed bibliographic metadata for PMID 41866701 at 2026-07-30T16:14:14.923Z. PubMed recorded a metadata revision date of 2026-06-08 and an Entrez history date of 2026-03-23. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained PubMed bibliographic metadata for PMID 41959165 at 2026-07-30T16:22:18.487Z. PubMed recorded a metadata revision date of 2026-04-27 and an Entrez history date of 2026-04-10. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained PubMed bibliographic metadata for PMID 41994885 at 2026-07-30T16:22:19.404Z. PubMed recorded a metadata revision date of 2026-04-17 and an Entrez history date of 2026-04-17. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained PubMed bibliographic metadata for PMID 42068058 at 2026-07-30T16:20:43.725Z. PubMed recorded a metadata revision date of 2026-05-02 and an Entrez history date of 2026-05-02. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained PubMed bibliographic metadata for PMID 42070740 at 2026-07-30T16:14:16.709Z. PubMed recorded a metadata revision date of 2026-06-13 and an Entrez history date of 2026-05-03. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained PubMed bibliographic metadata for PMID 42205046 at 2026-08-10T18:13:50.682Z. PubMed recorded a metadata revision date of 2026-07-06 and an Entrez history date of 2026-05-28. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained PubMed bibliographic metadata for PMID 42329358 at 2026-07-30T16:14:19.342Z. PubMed recorded a metadata revision date of 2026-06-22 and an Entrez history date of 2026-06-22. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained PubMed bibliographic metadata for PMID 32213649 at 2026-08-10T18:13:32.288Z. PubMed recorded a metadata revision date of 2026-07-10 and an Entrez history date of 2020-03-28. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained PubMed bibliographic metadata for PMID 41894554 at 2026-08-10T18:13:44.905Z. PubMed recorded a metadata revision date of 2026-07-26 and an Entrez history date of 2026-03-27. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained PubMed bibliographic metadata for PMID 42339090 at 2026-08-10T18:13:52.307Z. PubMed recorded a metadata revision date of 2026-07-14 and an Entrez history date of 2026-06-24. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained PubMed bibliographic metadata for PMID 42418774 at 2026-08-10T18:13:53.869Z. PubMed recorded a metadata revision date of 2026-07-09 and an Entrez history date of 2026-07-08. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained PubMed bibliographic metadata for PMID 42008191 at 2026-08-10T10:49:08.851Z. PubMed recorded a metadata revision date of 2026-07-30 and an Entrez history date of 2026-04-20. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained PubMed bibliographic metadata for PMID 42498078 at 2026-08-10T10:49:10.787Z. PubMed recorded a metadata revision date of 2026-08-01 and an Entrez history date of 2026-07-24. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained PubMed bibliographic metadata for PMID 42528856 at 2026-08-10T10:49:12.911Z. PubMed recorded a metadata revision date of 2026-07-30 and an Entrez history date of 2026-07-30. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained PubMed bibliographic metadata for PMID 42538728 at 2026-08-10T10:49:12.953Z. PubMed recorded a metadata revision date of 2026-08-01 and an Entrez history date of 2026-08-01. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.
PeptideScanner retained ClinicalTrials.gov record NCT02896192 at 2026-07-30T19:08:50.175Z. Its registry update date was 2023-09-21, and PeptideScanner's reviewed identity mapping was setmelanotide.
PeptideScanner retained ClinicalTrials.gov record NCT03262610 at 2026-07-30T19:44:52.963Z. Its registry update date was 2022-01-04, and PeptideScanner's reviewed identity mapping was setmelanotide.
PeptideScanner retained ClinicalTrials.gov record NCT03287960 at 2026-07-30T19:13:03.752Z. Its registry update date was 2023-05-23, and PeptideScanner's reviewed identity mapping was setmelanotide.
PeptideScanner retained ClinicalTrials.gov record NCT03651765 at 2026-07-30T18:27:14.161Z. Its registry update date was 2025-05-31, and PeptideScanner's reviewed identity mapping was setmelanotide.
PeptideScanner retained ClinicalTrials.gov record NCT04725240 at 2026-07-30T18:31:14.558Z. Its registry update date was 2025-02-07, and PeptideScanner's reviewed identity mapping was setmelanotide.
PeptideScanner retained ClinicalTrials.gov record NCT04966741 at 2026-07-30T18:38:25.516Z. Its registry update date was 2024-11-27, and PeptideScanner's reviewed identity mapping was setmelanotide.
PeptideScanner retained ClinicalTrials.gov record NCT05046132 at 2026-07-30T18:45:10.886Z. Its registry update date was 2024-05-03, and PeptideScanner's reviewed identity mapping was setmelanotide.
PeptideScanner retained ClinicalTrials.gov record NCT05774756 at 2026-07-30T16:19:36.905Z. Its registry update date was 2026-05-29, and PeptideScanner's reviewed identity mapping was setmelanotide.
PeptideScanner retained ClinicalTrials.gov record NCT06772597 at 2026-07-30T16:23:45.672Z. Its registry update date was 2026-02-12, and PeptideScanner's reviewed identity mapping was setmelanotide.