Cross-source evidence timeline

Setmelanotide research timeline

Follow 64 selected, directly cited source records from November 25, 2020 through August 6, 2026. This timeline joins source lanes for navigation; it does not infer that one record confirms another.

64Selected records
7Source years
3Evidence lanes
August 6, 2026Latest source date

Source year

2026

31 records
Literature metadata · 24Clinical trials · 5Regulatory · 2
  1. Clinical trials

    ClinicalTrials.gov record NCT05093634

    PeptideScanner retained ClinicalTrials.gov record NCT05093634 at 2026-08-13T05:52:27.024Z. Its registry update date was 2026-08-06, and PeptideScanner's reviewed identity mapping was setmelanotide.

  2. Literature metadata

    PubMed record PMID 42498078

    PeptideScanner retained PubMed bibliographic metadata for PMID 42498078 at 2026-08-10T10:49:10.787Z. PubMed recorded a metadata revision date of 2026-08-01 and an Entrez history date of 2026-07-24. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  3. Literature metadata

    PubMed record PMID 42538728

    PeptideScanner retained PubMed bibliographic metadata for PMID 42538728 at 2026-08-10T10:49:12.953Z. PubMed recorded a metadata revision date of 2026-08-01 and an Entrez history date of 2026-08-01. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  4. Literature metadata

    PubMed record PMID 42008191

    PeptideScanner retained PubMed bibliographic metadata for PMID 42008191 at 2026-08-10T10:49:08.851Z. PubMed recorded a metadata revision date of 2026-07-30 and an Entrez history date of 2026-04-20. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  5. Literature metadata

    PubMed record PMID 42528856

    PeptideScanner retained PubMed bibliographic metadata for PMID 42528856 at 2026-08-10T10:49:12.911Z. PubMed recorded a metadata revision date of 2026-07-30 and an Entrez history date of 2026-07-30. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  6. Literature metadata

    PubMed record PMID 41894554

    PeptideScanner retained PubMed bibliographic metadata for PMID 41894554 at 2026-08-10T18:13:44.905Z. PubMed recorded a metadata revision date of 2026-07-26 and an Entrez history date of 2026-03-27. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  7. Clinical trials

    ClinicalTrials.gov record NCT07496463

    PeptideScanner retained ClinicalTrials.gov record NCT07496463 at 2026-08-10T18:10:04.219Z. Its registry update date was 2026-07-23, and PeptideScanner's reviewed identity mapping was setmelanotide.

  8. Clinical trials

    ClinicalTrials.gov record NCT06596135

    PeptideScanner retained ClinicalTrials.gov record NCT06596135 at 2026-08-10T18:10:03.859Z. Its registry update date was 2026-07-15, and PeptideScanner's reviewed identity mapping was setmelanotide.

  9. Literature metadata

    PubMed record PMID 42339090

    PeptideScanner retained PubMed bibliographic metadata for PMID 42339090 at 2026-08-10T18:13:52.307Z. PubMed recorded a metadata revision date of 2026-07-14 and an Entrez history date of 2026-06-24. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  10. Literature metadata

    PubMed record PMID 32213649

    PeptideScanner retained PubMed bibliographic metadata for PMID 32213649 at 2026-08-10T18:13:32.288Z. PubMed recorded a metadata revision date of 2026-07-10 and an Entrez history date of 2020-03-28. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  11. Literature metadata

    PubMed record PMID 42418774

    PeptideScanner retained PubMed bibliographic metadata for PMID 42418774 at 2026-08-10T18:13:53.869Z. PubMed recorded a metadata revision date of 2026-07-09 and an Entrez history date of 2026-07-08. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  12. Literature metadata

    PubMed record PMID 42205046

    PeptideScanner retained PubMed bibliographic metadata for PMID 42205046 at 2026-08-10T18:13:50.682Z. PubMed recorded a metadata revision date of 2026-07-06 and an Entrez history date of 2026-05-28. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  13. Literature metadata

    PubMed record PMID 38567654

    PeptideScanner retained PubMed bibliographic metadata for PMID 38567654 at 2026-08-10T18:13:32.350Z. PubMed recorded a metadata revision date of 2026-07-04 and an Entrez history date of 2024-04-03. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  14. Literature metadata

    PubMed record PMID 42329358

    PeptideScanner retained PubMed bibliographic metadata for PMID 42329358 at 2026-07-30T16:14:19.342Z. PubMed recorded a metadata revision date of 2026-06-22 and an Entrez history date of 2026-06-22. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  15. Literature metadata

    PubMed record PMID 42070740

    PeptideScanner retained PubMed bibliographic metadata for PMID 42070740 at 2026-07-30T16:14:16.709Z. PubMed recorded a metadata revision date of 2026-06-13 and an Entrez history date of 2026-05-03. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  16. Literature metadata

    PubMed record PMID 34561620

    PeptideScanner retained PubMed bibliographic metadata for PMID 34561620 at 2026-07-30T16:14:06.776Z. PubMed recorded a metadata revision date of 2026-06-08 and an Entrez history date of 2021-09-25. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  17. Literature metadata

    PubMed record PMID 41866701

    PeptideScanner retained PubMed bibliographic metadata for PMID 41866701 at 2026-07-30T16:14:14.923Z. PubMed recorded a metadata revision date of 2026-06-08 and an Entrez history date of 2026-03-23. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  18. Clinical trials

    ClinicalTrials.gov record NCT05774756

    PeptideScanner retained ClinicalTrials.gov record NCT05774756 at 2026-07-30T16:19:36.905Z. Its registry update date was 2026-05-29, and PeptideScanner's reviewed identity mapping was setmelanotide.

  19. Literature metadata

    PubMed record PMID 33137293

    PeptideScanner retained PubMed bibliographic metadata for PMID 33137293 at 2026-07-30T16:20:34.542Z. PubMed recorded a metadata revision date of 2026-05-18 and an Entrez history date of 2020-11-02. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  20. Literature metadata

    PubMed record PMID 42068058

    PeptideScanner retained PubMed bibliographic metadata for PMID 42068058 at 2026-07-30T16:20:43.725Z. PubMed recorded a metadata revision date of 2026-05-02 and an Entrez history date of 2026-05-02. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  21. Literature metadata

    PubMed record PMID 41959165

    PeptideScanner retained PubMed bibliographic metadata for PMID 41959165 at 2026-07-30T16:22:18.487Z. PubMed recorded a metadata revision date of 2026-04-27 and an Entrez history date of 2026-04-10. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  22. Regulatory

    Federal Register rule 2026-07863

    The Federal Register published rule 2026-07863, attributed to FDA and its parent HHS department, on 2026-04-22. Its official title is “Medical Devices; Clinical Chemistry and Clinical Toxicology Devices; Classification of the Setmelanotide Eligibility Gene Variant Detection System,” and PeptideScanner's exact reviewed identity mapping connects the document to Setmelanotide.

  23. Literature metadata

    PubMed record PMID 38987029

    PeptideScanner retained PubMed bibliographic metadata for PMID 38987029 at 2026-07-30T16:22:12.162Z. PubMed recorded a metadata revision date of 2026-04-17 and an Entrez history date of 2024-07-10. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  24. Literature metadata

    PubMed record PMID 39284294

    PeptideScanner retained PubMed bibliographic metadata for PMID 39284294 at 2026-07-30T16:22:15.952Z. PubMed recorded a metadata revision date of 2026-04-17 and an Entrez history date of 2024-09-16. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  25. Literature metadata

    PubMed record PMID 41401696

    PeptideScanner retained PubMed bibliographic metadata for PMID 41401696 at 2026-07-30T16:22:18.312Z. PubMed recorded a metadata revision date of 2026-04-17 and an Entrez history date of 2025-12-16. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  26. Literature metadata

    PubMed record PMID 41994885

    PeptideScanner retained PubMed bibliographic metadata for PMID 41994885 at 2026-07-30T16:22:19.404Z. PubMed recorded a metadata revision date of 2026-04-17 and an Entrez history date of 2026-04-17. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  27. Regulatory

    Setmelanotide DailyMed SPL version 14

    DailyMed lists Structured Product Labeling version 14 for the reviewed Setmelanotide label family with a published date of 2026-04-02. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

  28. Literature metadata

    PubMed record PMID 40903014

    PeptideScanner retained PubMed bibliographic metadata for PMID 40903014 at 2026-07-30T16:25:12.584Z. PubMed recorded a metadata revision date of 2026-02-19 and an Entrez history date of 2025-09-03. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  29. Clinical trials

    ClinicalTrials.gov record NCT06772597

    PeptideScanner retained ClinicalTrials.gov record NCT06772597 at 2026-07-30T16:23:45.672Z. Its registry update date was 2026-02-12, and PeptideScanner's reviewed identity mapping was setmelanotide.

  30. Literature metadata

    PubMed record PMID 41601974

    PeptideScanner retained PubMed bibliographic metadata for PMID 41601974 at 2026-07-30T16:31:25.541Z. PubMed recorded a metadata revision date of 2026-01-31 and an Entrez history date of 2026-01-28. PeptideScanner associated this retained record with the identity slug setmelanotide. These dates describe PubMed metadata history, not the article's original publication date.

  31. Literature metadata

    Magel2-null mice are hyper-responsive to setmelanotide, a melanocortin 4 receptor agonist.

    PubMed lists PMID 27339818 in British journal of pharmacology as Journal Article, with publication-date metadata of 2016-07-27 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

Source year

2025

12 records
Literature metadata · 6Regulatory · 4Clinical trials · 2
  1. Regulatory

    Setmelanotide DailyMed SPL version 13

    DailyMed lists Structured Product Labeling version 13 for the reviewed Setmelanotide label family with a published date of 2025-12-22. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

  2. Literature metadata

    Carbocyclic setmelanotide analogs maintain biochemical potency at melanocortin 4 receptors.

    PubMed lists PMID 39394922 in Journal of peptide science : an official publication of the European Peptide Society as Journal Article, with publication-date metadata of 2024-10-12 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

  3. Regulatory

    Setmelanotide DailyMed SPL version 12

    DailyMed lists Structured Product Labeling version 12 for the reviewed Setmelanotide label family with a published date of 2025-09-05. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

  4. Literature metadata

    Development of Dysplastic Nevi in a Child with LEPR Deficiency Treated with Setmelanotide.

    PubMed lists PMID 40836563 in Journal of clinical research in pediatric endocrinology as Journal Article, with publication-date metadata of 2025-08-21 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

  5. Literature metadata

    Patient and caregiver experiences with a patient-support program for setmelanotide treatment of patients with Bardet-Biedl syndrome.

    PubMed lists PMID 40484968 in Orphanet journal of rare diseases as Journal Article, with publication-date metadata of 2025-06-08 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

  6. Clinical trials

    ClinicalTrials.gov record NCT03651765

    PeptideScanner retained ClinicalTrials.gov record NCT03651765 at 2026-07-30T18:27:14.161Z. Its registry update date was 2025-05-31, and PeptideScanner's reviewed identity mapping was setmelanotide.

  7. Literature metadata

    Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency.

    PubMed lists PMID 29031731 in Molecular metabolism as Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2017-07-08 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

  8. Regulatory

    Setmelanotide DailyMed SPL version 9

    DailyMed lists Structured Product Labeling version 9 for the reviewed Setmelanotide label family with a published date of 2025-05-23. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

  9. Literature metadata

    Setmelanotide: new promise for the treatment of hypothalamic obesity?

    PubMed lists PMID 38697183 in The lancet. Diabetes & endocrinology as Journal Article, Comment, with publication-date metadata of 2024-04-30 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

  10. Literature metadata

    Setmelanotide for the treatment of acquired hypothalamic obesity: a phase 2, open-label, multicentre trial.

    PubMed lists PMID 38697184 in The lancet. Diabetes & endocrinology as Journal Article, Clinical Trial, Phase II, Multicenter Study, Research Support, Non-U.S. Gov't, with publication-date metadata of 2024-04-30 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

  11. Regulatory

    Setmelanotide DailyMed SPL version 8

    DailyMed lists Structured Product Labeling version 8 for the reviewed Setmelanotide label family with a published date of 2025-05-19. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

  12. Clinical trials

    ClinicalTrials.gov record NCT04725240

    PeptideScanner retained ClinicalTrials.gov record NCT04725240 at 2026-07-30T18:31:14.558Z. Its registry update date was 2025-02-07, and PeptideScanner's reviewed identity mapping was setmelanotide.

Source year

2024

4 records
Clinical trials · 2Literature metadata · 2
  1. Literature metadata

    Setmelanotide for the treatment of severe early-childhood genetic obesity.

    PubMed lists PMID 39549717 in The lancet. Diabetes & endocrinology as Journal Article, with publication-date metadata of 2024-11-13 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

  2. Clinical trials

    ClinicalTrials.gov record NCT04966741

    PeptideScanner retained ClinicalTrials.gov record NCT04966741 at 2026-07-30T18:38:25.516Z. Its registry update date was 2024-11-27, and PeptideScanner's reviewed identity mapping was setmelanotide.

  3. Literature metadata

    Setmelanotide: A Melanocortin-4 Receptor Agonist for the Treatment of Severe Obesity Due to Hypothalamic Dysfunction.

    PubMed lists PMID 39526054 in TouchREVIEWS in endocrinology as Journal Article, Review, with publication-date metadata of 2024-02-09 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

  4. Clinical trials

    ClinicalTrials.gov record NCT05046132

    PeptideScanner retained ClinicalTrials.gov record NCT05046132 at 2026-07-30T18:45:10.886Z. Its registry update date was 2024-05-03, and PeptideScanner's reviewed identity mapping was setmelanotide.

Source year

2023

3 records
Clinical trials · 2Regulatory · 1
  1. Regulatory

    Setmelanotide DailyMed SPL version 6

    DailyMed lists Structured Product Labeling version 6 for the reviewed Setmelanotide label family with a published date of 2023-11-29. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

  2. Clinical trials

    ClinicalTrials.gov record NCT02896192

    PeptideScanner retained ClinicalTrials.gov record NCT02896192 at 2026-07-30T19:08:50.175Z. Its registry update date was 2023-09-21, and PeptideScanner's reviewed identity mapping was setmelanotide.

  3. Clinical trials

    ClinicalTrials.gov record NCT03287960

    PeptideScanner retained ClinicalTrials.gov record NCT03287960 at 2026-07-30T19:13:03.752Z. Its registry update date was 2023-05-23, and PeptideScanner's reviewed identity mapping was setmelanotide.

Source year

2022

7 records
Regulatory · 5Clinical trials · 1Literature metadata · 1
  1. Literature metadata

    Structural analysis of setmelanotide binding to MC4R variants in comparison to wild-type receptor.

    PubMed lists PMID 35931197 in Life sciences as Journal Article, with publication-date metadata of 2022-08-02 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

  2. Regulatory

    Federal Register notice 2022-16502

    The Federal Register published notice 2022-16502, attributed to FDA and its parent HHS department, on 2022-08-03. Its official title is “Product-Specific Guidances; Draft and Revised Draft Guidances for Industry; Availability,” and PeptideScanner's exact reviewed identity mapping connects the document to Setmelanotide.

  3. Regulatory

    Setmelanotide DailyMed SPL version 5

    DailyMed lists Structured Product Labeling version 5 for the reviewed Setmelanotide label family with a published date of 2022-07-04. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

  4. Regulatory

    Federal Register notice 2022-14134

    The Federal Register published notice 2022-14134, attributed to FDA and its parent HHS department, on 2022-07-01. Its official title is “Determination of Regulatory Review Period for Purposes of Patent Extension; IMCIVREE,” and PeptideScanner's exact reviewed identity mapping connects the document to Setmelanotide.

  5. Regulatory

    Setmelanotide DailyMed SPL version 4

    DailyMed lists Structured Product Labeling version 4 for the reviewed Setmelanotide label family with a published date of 2022-04-27. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

  6. Regulatory

    Setmelanotide DailyMed SPL version 3

    DailyMed lists Structured Product Labeling version 3 for the reviewed Setmelanotide label family with a published date of 2022-04-12. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

  7. Clinical trials

    ClinicalTrials.gov record NCT03262610

    PeptideScanner retained ClinicalTrials.gov record NCT03262610 at 2026-07-30T19:44:52.963Z. Its registry update date was 2022-01-04, and PeptideScanner's reviewed identity mapping was setmelanotide.

Source year

2021

4 records
Literature metadata · 4
  1. Literature metadata

    Setmelanotide: First Approval.

    PubMed lists PMID 33638809 in Drugs as Journal Article, Review, with publication-date metadata of 2021-02 (month precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

  2. Literature metadata

    Setmelanotide Acetate.

    PubMed lists PMID 33787829 in American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists as Journal Article, with publication-date metadata of 2021-03-31 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

  3. Literature metadata

    Setmelanotide (Imcivree) for rare genetic forms of obesity.

    PubMed lists PMID 34544109 in The Medical letter on drugs and therapeutics as Journal Article, Review, with publication-date metadata of 2021-07-26 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

  4. Literature metadata

    Setmelanotide: what does it mean for clinical care of patients with obesity?

    PubMed lists PMID 33137294 in The lancet. Diabetes & endocrinology as Journal Article, Comment, with publication-date metadata of 2020-10-30 (day precision). PeptideScanner associated the retained record with the identity slug setmelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

Source year

2020

3 records
Regulatory · 3
  1. Regulatory

    Federal Register notice 2020-27760

    The Federal Register published notice 2020-27760, attributed to FDA and its parent HHS department, on 2020-12-17. Its official title is “Issuance of Priority Review Voucher; Rare Pediatric Disease Product,” and PeptideScanner's exact reviewed identity mapping connects the document to Setmelanotide.

  2. Regulatory

    Setmelanotide DailyMed SPL version 1

    DailyMed lists Structured Product Labeling version 1 for the reviewed Setmelanotide label family with a published date of 2020-12-16. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

  3. Regulatory

    Drugs@FDA application NDA213793

    The official Drugs@FDA dataset lists original submission 1 for NDA 213793 with status AP dated 2020-11-25, and names setmelanotide acetate among the application record's active ingredients.