Profile change history

What changed for Linaclotide?

A deterministic history of records added to PeptideScanner and preserved profile or record revisions connected through the reviewed Linaclotide identity.

98Total events
97Record additions
1Version changes
15Cited source years

Before and after

Preserved version changes

Profile updated

Linaclotide profile

We rewrote the profile summary to describe the cited public record more directly. The cited sources and status did not change.

PeptideScanner change date
July 27, 2026
Evidence lane
Profile

Profile summary

Before
A guanylate cyclase-C agonist peptide represented in current U.S. drug-label records.
After
A guanylate cyclase-C agonist peptide. This profile cites a U.S. label record.

Collection chronology

Evidence added to PeptideScanner

Browse all 97 connected records →

Showing the latest 97 additions by PeptideScanner publication date; the complete connected record set remains available in Latest Research. Most recent addition: August 25, 2026.

Record added

FDA enforcement report D-0417-2021

FDA's dated enforcement report D-0417-2021 lists Class II and source status Terminated for Cardinal Health Inc. PeptideScanner connects the report to reviewed application NDA202811 through exact openFDA application-number annotations.

PeptideScanner change date
August 25, 2026
Cited source date
June 2, 2021
Evidence lane
Safety
Record added

Linaclotide DailyMed SPL version 10

DailyMed lists Structured Product Labeling version 10 for the reviewed Linaclotide label family with a published date of 2016-04-18. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
April 18, 2016
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 11

DailyMed lists Structured Product Labeling version 11 for the reviewed Linaclotide label family with a published date of 2016-09-20. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
September 20, 2016
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 12

DailyMed lists Structured Product Labeling version 12 for the reviewed Linaclotide label family with a published date of 2016-11-03. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
November 3, 2016
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 13

DailyMed lists Structured Product Labeling version 13 for the reviewed Linaclotide label family with a published date of 2017-02-15. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
February 15, 2017
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 14

DailyMed lists Structured Product Labeling version 14 for the reviewed Linaclotide label family with a published date of 2017-06-08. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
June 8, 2017
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 15

DailyMed lists Structured Product Labeling version 15 for the reviewed Linaclotide label family with a published date of 2017-06-26. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
June 26, 2017
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 16

DailyMed lists Structured Product Labeling version 16 for the reviewed Linaclotide label family with a published date of 2017-07-03. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
July 3, 2017
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 17

DailyMed lists Structured Product Labeling version 17 for the reviewed Linaclotide label family with a published date of 2017-11-02. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
November 2, 2017
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 18

DailyMed lists Structured Product Labeling version 18 for the reviewed Linaclotide label family with a published date of 2018-12-07. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
December 7, 2018
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 2

DailyMed lists Structured Product Labeling version 2 for the reviewed Linaclotide label family with a published date of 2012-09-11. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
September 11, 2012
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 23

DailyMed lists Structured Product Labeling version 23 for the reviewed Linaclotide label family with a published date of 2020-10-01. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
October 1, 2020
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 26

DailyMed lists Structured Product Labeling version 26 for the reviewed Linaclotide label family with a published date of 2021-04-16. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
April 16, 2021
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 27

DailyMed lists Structured Product Labeling version 27 for the reviewed Linaclotide label family with a published date of 2021-04-20. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
April 20, 2021
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 28

DailyMed lists Structured Product Labeling version 28 for the reviewed Linaclotide label family with a published date of 2021-09-08. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
September 8, 2021
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 30

DailyMed lists Structured Product Labeling version 30 for the reviewed Linaclotide label family with a published date of 2022-12-06. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
December 6, 2022
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 31

DailyMed lists Structured Product Labeling version 31 for the reviewed Linaclotide label family with a published date of 2023-05-05. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
May 5, 2023
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 32

DailyMed lists Structured Product Labeling version 32 for the reviewed Linaclotide label family with a published date of 2023-06-21. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
June 21, 2023
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 33

DailyMed lists Structured Product Labeling version 33 for the reviewed Linaclotide label family with a published date of 2023-09-21. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
September 21, 2023
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 34

DailyMed lists Structured Product Labeling version 34 for the reviewed Linaclotide label family with a published date of 2024-07-11. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
July 11, 2024
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 36

DailyMed lists Structured Product Labeling version 36 for the reviewed Linaclotide label family with a published date of 2025-11-17. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
November 17, 2025
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 38

DailyMed lists Structured Product Labeling version 38 for the reviewed Linaclotide label family with a published date of 2026-01-16. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
January 16, 2026
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 39

DailyMed lists Structured Product Labeling version 39 for the reviewed Linaclotide label family with a published date of 2026-06-01. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
June 1, 2026
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 4

DailyMed lists Structured Product Labeling version 4 for the reviewed Linaclotide label family with a published date of 2013-04-12. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
April 12, 2013
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 5

DailyMed lists Structured Product Labeling version 5 for the reviewed Linaclotide label family with a published date of 2013-08-06. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
August 6, 2013
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 6

DailyMed lists Structured Product Labeling version 6 for the reviewed Linaclotide label family with a published date of 2014-07-16. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
July 16, 2014
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 7

DailyMed lists Structured Product Labeling version 7 for the reviewed Linaclotide label family with a published date of 2014-07-17. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
July 17, 2014
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 8

DailyMed lists Structured Product Labeling version 8 for the reviewed Linaclotide label family with a published date of 2015-12-04. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
December 4, 2015
Evidence lane
Regulatory
Record added

Linaclotide DailyMed SPL version 9

DailyMed lists Structured Product Labeling version 9 for the reviewed Linaclotide label family with a published date of 2015-12-18. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.

PeptideScanner change date
August 22, 2026
Cited source date
December 18, 2015
Evidence lane
Regulatory
Record added

Federal Register notice 2014-11926

The Federal Register published notice 2014-11926, attributed to FDA and its parent HHS department, on 2014-05-23. Its official title is “Determination of Regulatory Review Period for Purposes of Patent Extension; LINZESS,” and PeptideScanner's exact reviewed identity mapping connects the document to Linaclotide.

PeptideScanner change date
August 21, 2026
Cited source date
May 23, 2014
Evidence lane
Regulatory
Record added

Federal Register notice 2018-28213

The Federal Register published notice 2018-28213, attributed to FDA and its parent HHS department, on 2018-12-28. Its official title is “Product-Specific Guidance for Linaclotide; Draft Guidance for Industry; Availability,” and PeptideScanner's exact reviewed identity mapping connects the document to Linaclotide.

PeptideScanner change date
August 21, 2026
Cited source date
December 28, 2018
Evidence lane
Regulatory
Record added

Federal Register notice 2022-10701

The Federal Register published notice 2022-10701, attributed to FDA and its parent HHS department, on 2022-05-20. Its official title is “Product-Specific Guidances; Draft and Revised Draft Guidances for Industry; Availability,” and PeptideScanner's exact reviewed identity mapping connects the document to Exenatide and Linaclotide.

PeptideScanner change date
August 21, 2026
Cited source date
May 20, 2022
Evidence lane
Regulatory
Record added

Federal Register notice 2025-19281

The Federal Register published notice 2025-19281, attributed to FDA and its parent HHS department, on 2025-10-02. Its official title is “Pediatric Advisory Committee (PAC); Notice of Meeting; Establishment of a Public Docket; Request for Comments,” and PeptideScanner's exact reviewed identity mapping connects the document to Exenatide and Linaclotide.

PeptideScanner change date
August 21, 2026
Cited source date
October 2, 2025
Evidence lane
Regulatory
Record added

Linaclotide (Linzess) for functional constipation.

PubMed lists PMID 37651297 in The Medical letter on drugs and therapeutics as Journal Article, with publication-date metadata of 2023-08-21 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 16, 2026
Cited source date
September 5, 2023
Evidence lane
Literature metadata
Record added

ClinicalTrials.gov record NCT03796884

PeptideScanner retained ClinicalTrials.gov record NCT03796884 at 2026-08-10T18:10:04.224Z. Its registry update date was 2026-07-22, and PeptideScanner's reviewed identity mapping was linaclotide.

PeptideScanner change date
August 14, 2026
Cited source date
July 22, 2026
Evidence lane
Clinical trials
Record added

ClinicalTrials.gov record NCT05652205

PeptideScanner retained ClinicalTrials.gov record NCT05652205 at 2026-07-30T16:19:36.913Z. Its registry update date was 2026-05-14, and PeptideScanner's reviewed identity mapping was linaclotide.

PeptideScanner change date
August 14, 2026
Cited source date
May 14, 2026
Evidence lane
Clinical trials
Record added

Diagnosis and treatment of irritable bowel syndrome with predominant constipation in the primary-care setting: focus on linaclotide.

PubMed lists PMID 29184433 in International journal of general medicine as Journal Article, Review, with publication-date metadata of 2017-10-31 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 14, 2026
Cited source date
March 27, 2024
Evidence lane
Literature metadata
Record added

UK clinical experience up to 52 weeks with linaclotide for irritable bowel syndrome with constipation.

PubMed lists PMID 30302125 in Therapeutic advances in gastroenterology as Journal Article, with publication-date metadata of 2018-10-03 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 14, 2026
Cited source date
September 28, 2023
Evidence lane
Literature metadata
Record added

Linaclotide and Prucalopride for Management of Constipation in Patients with Parkinsonism.

PubMed lists PMID 30746404 in Movement disorders clinical practice as Journal Article, with publication-date metadata of 2018-01-28 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 14, 2026
Cited source date
September 30, 2020
Evidence lane
Literature metadata
Record added

Pharmacotherapy patterns in patients with chronic idiopathic constipation beginning treatment with linaclotide or lubiprostone in the United States.

PubMed lists PMID 32863841 in Drugs in context as Journal Article, with publication-date metadata of 2020-08-12 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 14, 2026
Cited source date
November 12, 2023
Evidence lane
Literature metadata
Record added

ClinicalTrials.gov record NCT05796388

PeptideScanner retained ClinicalTrials.gov record NCT05796388 at 2026-08-10T18:10:03.859Z. Its registry update date was 2026-07-29, and PeptideScanner's reviewed identity mapping was linaclotide.

PeptideScanner change date
August 13, 2026
Cited source date
July 29, 2026
Evidence lane
Clinical trials
Record added

Clarification of trial end points presented in a recent review of linaclotide.

PubMed lists PMID 22149576 in Expert review of gastroenterology & hepatology as Letter, Comment, with publication-date metadata of 2012-02 (month precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
December 1, 2018
Evidence lane
Literature metadata
Record added

Linaclotide (Linzess) for constipation.

PubMed lists PMID 23183319 in The Medical letter on drugs and therapeutics as Journal Article, with publication-date metadata of 2012-11-12 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
January 28, 2026
Evidence lane
Literature metadata
Record added

An evaluation of the FDA responder endpoint for IBS-C clinical trials: analysis of data from linaclotide Phase 3 clinical trials.

PubMed lists PMID 23384406 in Neurogastroenterology and motility as Clinical Trial, Phase III, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, with publication-date metadata of 2013-02-06 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
January 28, 2026
Evidence lane
Literature metadata
Record added

Constella™(EU)-Linzess™(USA): the last milestone in the long journey of the peptide linaclotide and its implications for the future of peptide drugs.

PubMed lists PMID 23464519 in Future medicinal chemistry as Journal Article, Research Support, Non-U.S. Gov't, Review, with publication-date metadata of 2013-03 (month precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
November 16, 2017
Evidence lane
Literature metadata
Record added

Linaclotide for the treatment of irritable bowel syndrome with constipation: is it time to reshuffle the deck?

PubMed lists PMID 23791794 in Gastroenterology as Journal Article, Comment, with publication-date metadata of 2013-06-20 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
December 2, 2018
Evidence lane
Literature metadata
Record added

Clarification of linaclotide clinical trial information in a recent review on constipation.

PubMed lists PMID 23810343 in Gastroenterology as Letter, Comment, with publication-date metadata of 2013-06-26 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
December 2, 2018
Evidence lane
Literature metadata
Record added

Linaclotide in the treatment of patients with irritable bowel syndrome and constipation - analysis of an opportunity.

PubMed lists PMID 24090017 in Revista espanola de enfermedades digestivas as Journal Article, Review, with publication-date metadata of 2013-07 (month precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
September 18, 2019
Evidence lane
Literature metadata
Record added

Linaclotide for constipation-predominant IBS.

PubMed lists PMID 24227771 in Drug and therapeutics bulletin as Journal Article, with publication-date metadata of 2013-11 (month precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
November 16, 2017
Evidence lane
Literature metadata
Record added

Economic evaluation of linaclotide for the treatment of adult patients with irritable bowel syndrome with constipation in the United States.

PubMed lists PMID 25333331 in Journal of medical economics as Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2015-04 (month precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
November 16, 2017
Evidence lane
Literature metadata
Record added

Economic Evaluation of Linaclotide for the Treatment of Adult Patients With Chronic Idiopathic Constipation in the United States.

PubMed lists PMID 27008836 in Managed care (Langhorne, Pa.) as Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2016-02 (month precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
January 27, 2026
Evidence lane
Literature metadata
Record added

Bioactivity of Oral Linaclotide in Human Colorectum for Cancer Chemoprevention.

PubMed lists PMID 28396341 in Cancer prevention research (Philadelphia, Pa.) as Clinical Trial, Journal Article, with publication-date metadata of 2017-04-10 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
January 3, 2025
Evidence lane
Literature metadata
Record added

Health Care Resource Use and Costs Pre- and Post-Treatment Initiation With Linaclotide: Retrospective Analyses of a U.S. Insured Population.

PubMed lists PMID 29451468 in Managed care (Langhorne, Pa.) as Journal Article, with publication-date metadata of 2018-02 (month precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
January 27, 2026
Evidence lane
Literature metadata
Record added

Linaclotide for the treatment of chronic constipation.

PubMed lists PMID 29985664 in Expert opinion on pharmacotherapy as Clinical Trial, Phase II, Journal Article, Randomized Controlled Trial, with publication-date metadata of 2018-07-09 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
March 18, 2019
Evidence lane
Literature metadata
Record added

Engineering of an Anti-Inflammatory Peptide Based on the Disulfide-Rich Linaclotide Scaffold.

PubMed lists PMID 30301200 in Biomedicines as Journal Article, with publication-date metadata of 2018-10-06 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
September 30, 2020
Evidence lane
Literature metadata
Record added

Long-term treatment with linaclotide of intestinal pseudo-obstruction secondary to Ehlers-Danlos syndrome.

PubMed lists PMID 30470553 in Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver as Letter, with publication-date metadata of 2018-10-28 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
June 13, 2019
Evidence lane
Literature metadata
Record added

Linaclotide for paediatric functional constipation.

PubMed lists PMID 38211605 in The lancet. Gastroenterology & hepatology as Journal Article, Comment, with publication-date metadata of 2024-01-08 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
June 5, 2025
Evidence lane
Literature metadata
Record added

Characterization of disulfide bridges containing cyclic peptide Linaclotide and its degradation products by using LC-HRMS/MS.

PubMed lists PMID 39427438 in Journal of pharmaceutical and biomedical analysis as Journal Article, with publication-date metadata of 2024-10-17 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
January 27, 2026
Evidence lane
Literature metadata
Record added

Linaclotide as a Single Agent Bowel Preparation Regimen Before Colonoscopy.

PubMed lists PMID 39530977 in The American surgeon as Journal Article, with publication-date metadata of 2024-11-12 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
September 11, 2025
Evidence lane
Literature metadata
Record added

Linaclotide Use for the Treatment of Constipation and Gastrointestinal Symptoms in People With Cystic Fibrosis.

PubMed lists PMID 39620387 in Pediatric pulmonology as Journal Article, with publication-date metadata of 2024-12-02 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
May 17, 2025
Evidence lane
Literature metadata
Record added

PubMed record PMID 17694454

PeptideScanner retained PubMed bibliographic metadata for PMID 17694454 at 2026-07-30T21:22:56.977Z. PubMed recorded a metadata revision date of 2017-11-16 and an Entrez history date of 2007-08-19. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
November 16, 2017
Evidence lane
Literature metadata
Record added

PubMed record PMID 19098860

PeptideScanner retained PubMed bibliographic metadata for PMID 19098860 at 2026-07-30T21:22:56.979Z. PubMed recorded a metadata revision date of 2017-11-16 and an Entrez history date of 2008-12-23. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
November 16, 2017
Evidence lane
Literature metadata
Record added

PubMed record PMID 19706070

PeptideScanner retained PubMed bibliographic metadata for PMID 19706070 at 2026-07-30T21:22:57.963Z. PubMed recorded a metadata revision date of 2017-11-16 and an Entrez history date of 2009-08-27. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
November 16, 2017
Evidence lane
Literature metadata
Record added

PubMed record PMID 20560145

PeptideScanner retained PubMed bibliographic metadata for PMID 20560145 at 2026-07-30T21:22:57.971Z. PubMed recorded a metadata revision date of 2017-11-16 and an Entrez history date of 2010-06-19. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
November 16, 2017
Evidence lane
Literature metadata
Record added

PubMed record PMID 27200765

PeptideScanner retained PubMed bibliographic metadata for PMID 27200765 at 2026-07-30T21:38:23.145Z. PubMed recorded a metadata revision date of 2016-05-21 and an Entrez history date of 2016-05-21. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
May 21, 2016
Evidence lane
Literature metadata
Record added

PubMed record PMID 33858329

PeptideScanner retained PubMed bibliographic metadata for PMID 33858329 at 2026-07-30T16:22:11.958Z. PubMed recorded a metadata revision date of 2026-04-06 and an Entrez history date of 2021-04-16. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
April 6, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 38159221

PeptideScanner retained PubMed bibliographic metadata for PMID 38159221 at 2026-07-30T16:20:36.597Z. PubMed recorded a metadata revision date of 2026-05-15 and an Entrez history date of 2023-12-30. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
May 15, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 38533633

PeptideScanner retained PubMed bibliographic metadata for PMID 38533633 at 2026-07-30T16:14:06.902Z. PubMed recorded a metadata revision date of 2026-06-26 and an Entrez history date of 2024-03-27. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 26, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 38869953

PeptideScanner retained PubMed bibliographic metadata for PMID 38869953 at 2026-07-30T16:14:08.743Z. PubMed recorded a metadata revision date of 2026-06-16 and an Entrez history date of 2024-06-13. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 16, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 39370607

PeptideScanner retained PubMed bibliographic metadata for PMID 39370607 at 2026-07-30T16:11:44.834Z. PubMed recorded a metadata revision date of 2026-07-01 and an Entrez history date of 2024-10-07. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
July 1, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 39527338

PeptideScanner retained PubMed bibliographic metadata for PMID 39527338 at 2026-07-30T16:14:08.881Z. PubMed recorded a metadata revision date of 2026-06-23 and an Entrez history date of 2024-11-11. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 23, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 40423516

PeptideScanner retained PubMed bibliographic metadata for PMID 40423516 at 2026-07-30T16:23:36.824Z. PubMed recorded a metadata revision date of 2026-03-26 and an Entrez history date of 2025-05-27. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
March 26, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 41123247

PeptideScanner retained PubMed bibliographic metadata for PMID 41123247 at 2026-07-30T16:22:16.181Z. PubMed recorded a metadata revision date of 2026-04-10 and an Entrez history date of 2025-10-22. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
April 10, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 41413756

PeptideScanner retained PubMed bibliographic metadata for PMID 41413756 at 2026-07-30T16:14:13.037Z. PubMed recorded a metadata revision date of 2026-06-05 and an Entrez history date of 2025-12-18. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 5, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 41539984

PeptideScanner retained PubMed bibliographic metadata for PMID 41539984 at 2026-07-30T16:14:14.760Z. PubMed recorded a metadata revision date of 2026-06-26 and an Entrez history date of 2026-01-15. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 26, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42083746

PeptideScanner retained PubMed bibliographic metadata for PMID 42083746 at 2026-08-10T18:13:48.845Z. PubMed recorded a metadata revision date of 2026-07-16 and an Entrez history date of 2026-05-05. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
July 16, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 38962910

PeptideScanner retained PubMed bibliographic metadata for PMID 38962910 at 2026-08-10T18:13:32.376Z. PubMed recorded a metadata revision date of 2026-07-23 and an Entrez history date of 2024-07-04. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 11, 2026
Cited source date
July 23, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42009975

PeptideScanner retained PubMed bibliographic metadata for PMID 42009975 at 2026-08-10T18:13:48.763Z. PubMed recorded a metadata revision date of 2026-07-26 and an Entrez history date of 2026-04-20. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 11, 2026
Cited source date
July 26, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42465095

PeptideScanner retained PubMed bibliographic metadata for PMID 42465095 at 2026-08-10T18:13:55.292Z. PubMed recorded a metadata revision date of 2026-07-17 and an Entrez history date of 2026-07-17. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 11, 2026
Cited source date
July 17, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42482900

PeptideScanner retained PubMed bibliographic metadata for PMID 42482900 at 2026-08-10T18:13:56.703Z. PubMed recorded a metadata revision date of 2026-07-22 and an Entrez history date of 2026-07-22. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 11, 2026
Cited source date
July 22, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 41692643

PeptideScanner retained PubMed bibliographic metadata for PMID 41692643 at 2026-08-10T10:49:08.765Z. PubMed recorded a metadata revision date of 2026-08-03 and an Entrez history date of 2026-02-15. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 10, 2026
Cited source date
August 3, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 41913506

PeptideScanner retained PubMed bibliographic metadata for PMID 41913506 at 2026-08-10T18:13:46.784Z. PubMed recorded a metadata revision date of 2026-07-28 and an Entrez history date of 2026-03-31. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 10, 2026
Cited source date
July 28, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42425925

PeptideScanner retained PubMed bibliographic metadata for PMID 42425925 at 2026-08-10T10:49:10.758Z. PubMed recorded a metadata revision date of 2026-08-03 and an Entrez history date of 2026-07-09. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 10, 2026
Cited source date
August 3, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42523615

PeptideScanner retained PubMed bibliographic metadata for PMID 42523615 at 2026-08-10T18:13:56.783Z. PubMed recorded a metadata revision date of 2026-07-29 and an Entrez history date of 2026-07-29. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 10, 2026
Cited source date
July 29, 2026
Evidence lane
Literature metadata
Record added

ClinicalTrials.gov record NCT00730015

PeptideScanner retained ClinicalTrials.gov record NCT00730015 at 2026-07-30T21:55:56.622Z. Its registry update date was 2013-01-30, and PeptideScanner's reviewed identity mapping was linaclotide.

PeptideScanner change date
August 9, 2026
Cited source date
January 30, 2013
Evidence lane
Clinical trials
Record added

ClinicalTrials.gov record NCT00730171

PeptideScanner retained ClinicalTrials.gov record NCT00730171 at 2026-07-30T21:12:47.419Z. Its registry update date was 2018-02-19, and PeptideScanner's reviewed identity mapping was linaclotide.

PeptideScanner change date
August 9, 2026
Cited source date
February 19, 2018
Evidence lane
Clinical trials
Record added

ClinicalTrials.gov record NCT00765999

PeptideScanner retained ClinicalTrials.gov record NCT00765999 at 2026-07-30T20:56:08.251Z. Its registry update date was 2019-02-15, and PeptideScanner's reviewed identity mapping was linaclotide.

PeptideScanner change date
August 9, 2026
Cited source date
February 15, 2019
Evidence lane
Clinical trials
Record added

ClinicalTrials.gov record NCT02078323

PeptideScanner retained ClinicalTrials.gov record NCT02078323 at 2026-07-30T21:10:02.997Z. Its registry update date was 2018-07-23, and PeptideScanner's reviewed identity mapping was linaclotide.

PeptideScanner change date
August 9, 2026
Cited source date
July 23, 2018
Evidence lane
Clinical trials
Record added

ClinicalTrials.gov record NCT02220348

PeptideScanner retained ClinicalTrials.gov record NCT02220348 at 2026-07-30T20:18:37.979Z. Its registry update date was 2020-12-19, and PeptideScanner's reviewed identity mapping was linaclotide.

PeptideScanner change date
August 9, 2026
Cited source date
December 19, 2020
Evidence lane
Clinical trials
Record added

ClinicalTrials.gov record NCT02291679

PeptideScanner retained ClinicalTrials.gov record NCT02291679 at 2026-07-30T21:24:24.231Z. Its registry update date was 2017-06-15, and PeptideScanner's reviewed identity mapping was linaclotide.

PeptideScanner change date
August 9, 2026
Cited source date
June 15, 2017
Evidence lane
Clinical trials
Record added

ClinicalTrials.gov record NCT02559206

PeptideScanner retained ClinicalTrials.gov record NCT02559206 at 2026-07-30T20:29:13.579Z. Its registry update date was 2020-04-24, and PeptideScanner's reviewed identity mapping was linaclotide.

PeptideScanner change date
August 9, 2026
Cited source date
April 24, 2020
Evidence lane
Clinical trials
Record added

ClinicalTrials.gov record NCT03471728

PeptideScanner retained ClinicalTrials.gov record NCT03471728 at 2026-07-30T18:39:33.779Z. Its registry update date was 2024-10-18, and PeptideScanner's reviewed identity mapping was linaclotide.

PeptideScanner change date
August 9, 2026
Cited source date
October 18, 2024
Evidence lane
Clinical trials
Record added

ClinicalTrials.gov record NCT01950403

PeptideScanner retained ClinicalTrials.gov record NCT01950403 at 2026-07-30T18:37:14.701Z. Its registry update date was 2024-12-09, and PeptideScanner's reviewed identity mapping was linaclotide.

PeptideScanner change date
August 8, 2026
Cited source date
December 9, 2024
Evidence lane
Clinical trials
Record added

ClinicalTrials.gov record NCT03119584

PeptideScanner retained ClinicalTrials.gov record NCT03119584 at 2026-07-30T16:20:49.311Z. Its registry update date was 2026-04-03, and PeptideScanner's reviewed identity mapping was linaclotide.

PeptideScanner change date
August 8, 2026
Cited source date
April 3, 2026
Evidence lane
Clinical trials