Cross-source evidence timeline
Linaclotide research timeline
Follow 100 selected, directly cited source records from August 30, 2012 through August 3, 2026. This timeline joins source lanes for navigation; it does not infer that one record confirms another.
Source year
2026
Literature metadata
PubMed record PMID 41692643↗
PeptideScanner retained PubMed bibliographic metadata for PMID 41692643 at 2026-08-10T10:49:08.765Z. PubMed recorded a metadata revision date of 2026-08-03 and an Entrez history date of 2026-02-15. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 10, 2026Literature metadata
PubMed record PMID 42425925↗
PeptideScanner retained PubMed bibliographic metadata for PMID 42425925 at 2026-08-10T10:49:10.758Z. PubMed recorded a metadata revision date of 2026-08-03 and an Entrez history date of 2026-07-09. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 10, 2026Clinical trials
ClinicalTrials.gov record NCT05796388↗
PeptideScanner retained ClinicalTrials.gov record NCT05796388 at 2026-08-10T18:10:03.859Z. Its registry update date was 2026-07-29, and PeptideScanner's reviewed identity mapping was linaclotide.↗
Added to PeptideScanner August 13, 2026Literature metadata
PubMed record PMID 42523615↗
PeptideScanner retained PubMed bibliographic metadata for PMID 42523615 at 2026-08-10T18:13:56.783Z. PubMed recorded a metadata revision date of 2026-07-29 and an Entrez history date of 2026-07-29. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 10, 2026Literature metadata
PubMed record PMID 41913506↗
PeptideScanner retained PubMed bibliographic metadata for PMID 41913506 at 2026-08-10T18:13:46.784Z. PubMed recorded a metadata revision date of 2026-07-28 and an Entrez history date of 2026-03-31. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 10, 2026Literature metadata
PubMed record PMID 42009975↗
PeptideScanner retained PubMed bibliographic metadata for PMID 42009975 at 2026-08-10T18:13:48.763Z. PubMed recorded a metadata revision date of 2026-07-26 and an Entrez history date of 2026-04-20. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 11, 2026Literature metadata
PubMed record PMID 38962910↗
PeptideScanner retained PubMed bibliographic metadata for PMID 38962910 at 2026-08-10T18:13:32.376Z. PubMed recorded a metadata revision date of 2026-07-23 and an Entrez history date of 2024-07-04. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 11, 2026Clinical trials
ClinicalTrials.gov record NCT03796884↗
PeptideScanner retained ClinicalTrials.gov record NCT03796884 at 2026-08-10T18:10:04.224Z. Its registry update date was 2026-07-22, and PeptideScanner's reviewed identity mapping was linaclotide.↗
Added to PeptideScanner August 14, 2026Literature metadata
PubMed record PMID 42482900↗
PeptideScanner retained PubMed bibliographic metadata for PMID 42482900 at 2026-08-10T18:13:56.703Z. PubMed recorded a metadata revision date of 2026-07-22 and an Entrez history date of 2026-07-22. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 11, 2026Literature metadata
PubMed record PMID 42465095↗
PeptideScanner retained PubMed bibliographic metadata for PMID 42465095 at 2026-08-10T18:13:55.292Z. PubMed recorded a metadata revision date of 2026-07-17 and an Entrez history date of 2026-07-17. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 11, 2026Literature metadata
PubMed record PMID 42083746↗
PeptideScanner retained PubMed bibliographic metadata for PMID 42083746 at 2026-08-10T18:13:48.845Z. PubMed recorded a metadata revision date of 2026-07-16 and an Entrez history date of 2026-05-05. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Literature metadata
PubMed record PMID 39370607↗
PeptideScanner retained PubMed bibliographic metadata for PMID 39370607 at 2026-07-30T16:11:44.834Z. PubMed recorded a metadata revision date of 2026-07-01 and an Entrez history date of 2024-10-07. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Literature metadata
PubMed record PMID 38533633↗
PeptideScanner retained PubMed bibliographic metadata for PMID 38533633 at 2026-07-30T16:14:06.902Z. PubMed recorded a metadata revision date of 2026-06-26 and an Entrez history date of 2024-03-27. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Literature metadata
PubMed record PMID 41539984↗
PeptideScanner retained PubMed bibliographic metadata for PMID 41539984 at 2026-07-30T16:14:14.760Z. PubMed recorded a metadata revision date of 2026-06-26 and an Entrez history date of 2026-01-15. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Literature metadata
PubMed record PMID 39527338↗
PeptideScanner retained PubMed bibliographic metadata for PMID 39527338 at 2026-07-30T16:14:08.881Z. PubMed recorded a metadata revision date of 2026-06-23 and an Entrez history date of 2024-11-11. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Literature metadata
PubMed record PMID 38869953↗
PeptideScanner retained PubMed bibliographic metadata for PMID 38869953 at 2026-07-30T16:14:08.743Z. PubMed recorded a metadata revision date of 2026-06-16 and an Entrez history date of 2024-06-13. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Literature metadata
PubMed record PMID 41413756↗
PeptideScanner retained PubMed bibliographic metadata for PMID 41413756 at 2026-07-30T16:14:13.037Z. PubMed recorded a metadata revision date of 2026-06-05 and an Entrez history date of 2025-12-18. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Regulatory
Linaclotide DailyMed SPL version 39↗
DailyMed lists Structured Product Labeling version 39 for the reviewed Linaclotide label family with a published date of 2026-06-01. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Literature metadata
PubMed record PMID 38159221↗
PeptideScanner retained PubMed bibliographic metadata for PMID 38159221 at 2026-07-30T16:20:36.597Z. PubMed recorded a metadata revision date of 2026-05-15 and an Entrez history date of 2023-12-30. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Clinical trials
ClinicalTrials.gov record NCT05652205↗
PeptideScanner retained ClinicalTrials.gov record NCT05652205 at 2026-07-30T16:19:36.913Z. Its registry update date was 2026-05-14, and PeptideScanner's reviewed identity mapping was linaclotide.↗
Added to PeptideScanner August 14, 2026Literature metadata
PubMed record PMID 41123247↗
PeptideScanner retained PubMed bibliographic metadata for PMID 41123247 at 2026-07-30T16:22:16.181Z. PubMed recorded a metadata revision date of 2026-04-10 and an Entrez history date of 2025-10-22. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Literature metadata
PubMed record PMID 33858329↗
PeptideScanner retained PubMed bibliographic metadata for PMID 33858329 at 2026-07-30T16:22:11.958Z. PubMed recorded a metadata revision date of 2026-04-06 and an Entrez history date of 2021-04-16. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Clinical trials
ClinicalTrials.gov record NCT03119584↗
PeptideScanner retained ClinicalTrials.gov record NCT03119584 at 2026-07-30T16:20:49.311Z. Its registry update date was 2026-04-03, and PeptideScanner's reviewed identity mapping was linaclotide.↗
Added to PeptideScanner August 8, 2026Literature metadata
PubMed record PMID 40423516↗
PeptideScanner retained PubMed bibliographic metadata for PMID 40423516 at 2026-07-30T16:23:36.824Z. PubMed recorded a metadata revision date of 2026-03-26 and an Entrez history date of 2025-05-27. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Literature metadata
Linaclotide (Linzess) for constipation.↗
PubMed lists PMID 23183319 in The Medical letter on drugs and therapeutics as Journal Article, with publication-date metadata of 2012-11-12 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: November 12, 2012 · day precisionAdded to PeptideScanner August 13, 2026Literature metadata
An evaluation of the FDA responder endpoint for IBS-C clinical trials: analysis of data from linaclotide Phase 3 clinical trials.↗
PubMed lists PMID 23384406 in Neurogastroenterology and motility as Clinical Trial, Phase III, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, with publication-date metadata of 2013-02-06 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: February 6, 2013 · day precisionAdded to PeptideScanner August 13, 2026Literature metadata
Economic Evaluation of Linaclotide for the Treatment of Adult Patients With Chronic Idiopathic Constipation in the United States.↗
PubMed lists PMID 27008836 in Managed care (Langhorne, Pa.) as Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2016-02 (month precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: February 2016 · month precisionAdded to PeptideScanner August 13, 2026Literature metadata
Health Care Resource Use and Costs Pre- and Post-Treatment Initiation With Linaclotide: Retrospective Analyses of a U.S. Insured Population.↗
PubMed lists PMID 29451468 in Managed care (Langhorne, Pa.) as Journal Article, with publication-date metadata of 2018-02 (month precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: February 2018 · month precisionAdded to PeptideScanner August 13, 2026Literature metadata
Characterization of disulfide bridges containing cyclic peptide Linaclotide and its degradation products by using LC-HRMS/MS.↗
PubMed lists PMID 39427438 in Journal of pharmaceutical and biomedical analysis as Journal Article, with publication-date metadata of 2024-10-17 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: October 17, 2024 · day precisionAdded to PeptideScanner August 13, 2026Regulatory
Linaclotide DailyMed SPL version 38↗
DailyMed lists Structured Product Labeling version 38 for the reviewed Linaclotide label family with a published date of 2026-01-16. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Clinical trials
ClinicalTrials.gov record NCT05760313↗
PeptideScanner retained ClinicalTrials.gov record NCT05760313 at 2026-07-30T16:25:18.002Z. Its registry update date was 2026-01-06, and PeptideScanner's reviewed identity mapping was linaclotide.↗
Added to PeptideScanner September 9, 2026
Source year
2025
Regulatory
Linaclotide DailyMed SPL version 36↗
DailyMed lists Structured Product Labeling version 36 for the reviewed Linaclotide label family with a published date of 2025-11-17. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Regulatory
Federal Register notice 2025-19281↗
The Federal Register published notice 2025-19281, attributed to FDA and its parent HHS department, on 2025-10-02. Its official title is “Pediatric Advisory Committee (PAC); Notice of Meeting; Establishment of a Public Docket; Request for Comments,” and PeptideScanner's exact reviewed identity mapping connects the document to Exenatide and Linaclotide.↗
Added to PeptideScanner August 21, 2026Literature metadata
Linaclotide as a Single Agent Bowel Preparation Regimen Before Colonoscopy.↗
PubMed lists PMID 39530977 in The American surgeon as Journal Article, with publication-date metadata of 2024-11-12 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: November 12, 2024 · day precisionAdded to PeptideScanner August 13, 2026Literature metadata
Linaclotide for paediatric functional constipation.↗
PubMed lists PMID 38211605 in The lancet. Gastroenterology & hepatology as Journal Article, Comment, with publication-date metadata of 2024-01-08 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: January 8, 2024 · day precisionAdded to PeptideScanner August 13, 2026Literature metadata
Linaclotide Use for the Treatment of Constipation and Gastrointestinal Symptoms in People With Cystic Fibrosis.↗
PubMed lists PMID 39620387 in Pediatric pulmonology as Journal Article, with publication-date metadata of 2024-12-02 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: December 2, 2024 · day precisionAdded to PeptideScanner August 13, 2026Literature metadata
Bioactivity of Oral Linaclotide in Human Colorectum for Cancer Chemoprevention.↗
PubMed lists PMID 28396341 in Cancer prevention research (Philadelphia, Pa.) as Clinical Trial, Journal Article, with publication-date metadata of 2017-04-10 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: April 10, 2017 · day precisionAdded to PeptideScanner August 13, 2026
Source year
2024
Clinical trials
ClinicalTrials.gov record NCT01950403↗
PeptideScanner retained ClinicalTrials.gov record NCT01950403 at 2026-07-30T18:37:14.701Z. Its registry update date was 2024-12-09, and PeptideScanner's reviewed identity mapping was linaclotide.↗
Added to PeptideScanner August 8, 2026Clinical trials
ClinicalTrials.gov record NCT03471728↗
PeptideScanner retained ClinicalTrials.gov record NCT03471728 at 2026-07-30T18:39:33.779Z. Its registry update date was 2024-10-18, and PeptideScanner's reviewed identity mapping was linaclotide.↗
Added to PeptideScanner August 9, 2026Regulatory
Linaclotide DailyMed SPL version 34↗
DailyMed lists Structured Product Labeling version 34 for the reviewed Linaclotide label family with a published date of 2024-07-11. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Literature metadata
Diagnosis and treatment of irritable bowel syndrome with predominant constipation in the primary-care setting: focus on linaclotide.↗
PubMed lists PMID 29184433 in International journal of general medicine as Journal Article, Review, with publication-date metadata of 2017-10-31 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: October 31, 2017 · day precisionAdded to PeptideScanner August 14, 2026
Source year
2023
Literature metadata
Pharmacotherapy patterns in patients with chronic idiopathic constipation beginning treatment with linaclotide or lubiprostone in the United States.↗
PubMed lists PMID 32863841 in Drugs in context as Journal Article, with publication-date metadata of 2020-08-12 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: August 12, 2020 · day precisionAdded to PeptideScanner August 14, 2026Literature metadata
UK clinical experience up to 52 weeks with linaclotide for irritable bowel syndrome with constipation.↗
PubMed lists PMID 30302125 in Therapeutic advances in gastroenterology as Journal Article, with publication-date metadata of 2018-10-03 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: October 3, 2018 · day precisionAdded to PeptideScanner August 14, 2026Regulatory
Linaclotide DailyMed SPL version 33↗
DailyMed lists Structured Product Labeling version 33 for the reviewed Linaclotide label family with a published date of 2023-09-21. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Literature metadata
Linaclotide (Linzess) for functional constipation.↗
PubMed lists PMID 37651297 in The Medical letter on drugs and therapeutics as Journal Article, with publication-date metadata of 2023-08-21 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: August 21, 2023 · day precisionAdded to PeptideScanner August 16, 2026Regulatory
Linaclotide DailyMed SPL version 32↗
DailyMed lists Structured Product Labeling version 32 for the reviewed Linaclotide label family with a published date of 2023-06-21. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Regulatory
Linaclotide DailyMed SPL version 31↗
DailyMed lists Structured Product Labeling version 31 for the reviewed Linaclotide label family with a published date of 2023-05-05. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Literature metadata
Editorial: repurposed linaclotide and the quest for abdominal pain management in irritable bowel syndrome.↗
PubMed lists PMID 36565004 in Alimentary pharmacology & therapeutics as Editorial, Comment, with publication-date metadata of 2023-01 (month precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: January 2023 · month precisionAdded to PeptideScanner September 9, 2026Regulatory
Drugs@FDA application ANDA209611↗
The official Drugs@FDA dataset lists original submission 1 for ANDA 209611 with status AP dated 2023-02-07, and names linaclotide among the application record's active ingredients.↗
Added to PeptideScanner August 14, 2026
Source year
2022
Regulatory
Linaclotide DailyMed SPL version 30↗
DailyMed lists Structured Product Labeling version 30 for the reviewed Linaclotide label family with a published date of 2022-12-06. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Regulatory
Federal Register notice 2022-10701↗
The Federal Register published notice 2022-10701, attributed to FDA and its parent HHS department, on 2022-05-20. Its official title is “Product-Specific Guidances; Draft and Revised Draft Guidances for Industry; Availability,” and PeptideScanner's exact reviewed identity mapping connects the document to Exenatide and Linaclotide.↗
Added to PeptideScanner August 21, 2026
Source year
2021
Regulatory
Linaclotide DailyMed SPL version 28↗
DailyMed lists Structured Product Labeling version 28 for the reviewed Linaclotide label family with a published date of 2021-09-08. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Safety
FDA enforcement report D-0417-2021↗
FDA's dated enforcement report D-0417-2021 lists Class II and source status Terminated for Cardinal Health Inc. PeptideScanner connects the report to reviewed application NDA202811 through exact openFDA application-number annotations.↗
Added to PeptideScanner August 25, 2026Regulatory
Linaclotide DailyMed SPL version 27↗
DailyMed lists Structured Product Labeling version 27 for the reviewed Linaclotide label family with a published date of 2021-04-20. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Regulatory
Linaclotide DailyMed SPL version 26↗
DailyMed lists Structured Product Labeling version 26 for the reviewed Linaclotide label family with a published date of 2021-04-16. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Regulatory
Drugs@FDA application ANDA209564↗
The official Drugs@FDA dataset lists original submission 1 for ANDA 209564 with status AP dated 2021-02-09, and names linaclotide among the application record's active ingredients.↗
Added to PeptideScanner August 14, 2026
Source year
2020
Clinical trials
ClinicalTrials.gov record NCT02220348↗
PeptideScanner retained ClinicalTrials.gov record NCT02220348 at 2026-07-30T20:18:37.979Z. Its registry update date was 2020-12-19, and PeptideScanner's reviewed identity mapping was linaclotide.↗
Added to PeptideScanner August 9, 2026Clinical trials
ClinicalTrials.gov record NCT03573908↗
PeptideScanner retained ClinicalTrials.gov record NCT03573908 at 2026-07-30T20:18:37.978Z. Its registry update date was 2020-12-01, and PeptideScanner's reviewed identity mapping was linaclotide.↗
Added to PeptideScanner September 9, 2026Regulatory
Linaclotide DailyMed SPL version 23↗
DailyMed lists Structured Product Labeling version 23 for the reviewed Linaclotide label family with a published date of 2020-10-01. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Literature metadata
Linaclotide and Prucalopride for Management of Constipation in Patients with Parkinsonism.↗
PubMed lists PMID 30746404 in Movement disorders clinical practice as Journal Article, with publication-date metadata of 2018-01-28 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: January 28, 2018 · day precisionAdded to PeptideScanner August 14, 2026Literature metadata
Engineering of an Anti-Inflammatory Peptide Based on the Disulfide-Rich Linaclotide Scaffold.↗
PubMed lists PMID 30301200 in Biomedicines as Journal Article, with publication-date metadata of 2018-10-06 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: October 6, 2018 · day precisionAdded to PeptideScanner August 13, 2026Clinical trials
ClinicalTrials.gov record NCT02559206↗
PeptideScanner retained ClinicalTrials.gov record NCT02559206 at 2026-07-30T20:29:13.579Z. Its registry update date was 2020-04-24, and PeptideScanner's reviewed identity mapping was linaclotide.↗
Added to PeptideScanner August 9, 2026
Source year
2019
Literature metadata
Linaclotide in the treatment of patients with irritable bowel syndrome and constipation - analysis of an opportunity.↗
PubMed lists PMID 24090017 in Revista espanola de enfermedades digestivas as Journal Article, Review, with publication-date metadata of 2013-07 (month precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: July 2013 · month precisionAdded to PeptideScanner August 13, 2026Literature metadata
Long-term treatment with linaclotide of intestinal pseudo-obstruction secondary to Ehlers-Danlos syndrome.↗
PubMed lists PMID 30470553 in Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver as Letter, with publication-date metadata of 2018-10-28 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: October 28, 2018 · day precisionAdded to PeptideScanner August 13, 2026Literature metadata
Linaclotide for the treatment of chronic constipation.↗
PubMed lists PMID 29985664 in Expert opinion on pharmacotherapy as Clinical Trial, Phase II, Journal Article, Randomized Controlled Trial, with publication-date metadata of 2018-07-09 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: July 9, 2018 · day precisionAdded to PeptideScanner August 13, 2026Clinical trials
ClinicalTrials.gov record NCT00765999↗
PeptideScanner retained ClinicalTrials.gov record NCT00765999 at 2026-07-30T20:56:08.251Z. Its registry update date was 2019-02-15, and PeptideScanner's reviewed identity mapping was linaclotide.↗
Added to PeptideScanner August 9, 2026
Source year
2018
Regulatory
Federal Register notice 2018-28213↗
The Federal Register published notice 2018-28213, attributed to FDA and its parent HHS department, on 2018-12-28. Its official title is “Product-Specific Guidance for Linaclotide; Draft Guidance for Industry; Availability,” and PeptideScanner's exact reviewed identity mapping connects the document to Linaclotide.↗
Added to PeptideScanner August 21, 2026Regulatory
Linaclotide DailyMed SPL version 18↗
DailyMed lists Structured Product Labeling version 18 for the reviewed Linaclotide label family with a published date of 2018-12-07. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Literature metadata
Linaclotide for the treatment of irritable bowel syndrome with constipation: is it time to reshuffle the deck?↗
PubMed lists PMID 23791794 in Gastroenterology as Journal Article, Comment, with publication-date metadata of 2013-06-20 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: June 20, 2013 · day precisionAdded to PeptideScanner August 13, 2026Literature metadata
Clarification of linaclotide clinical trial information in a recent review on constipation.↗
PubMed lists PMID 23810343 in Gastroenterology as Letter, Comment, with publication-date metadata of 2013-06-26 (day precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: June 26, 2013 · day precisionAdded to PeptideScanner August 13, 2026Literature metadata
Clarification of trial end points presented in a recent review of linaclotide.↗
PubMed lists PMID 22149576 in Expert review of gastroenterology & hepatology as Letter, Comment, with publication-date metadata of 2012-02 (month precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: February 2012 · month precisionAdded to PeptideScanner August 13, 2026Clinical trials
ClinicalTrials.gov record NCT02078323↗
PeptideScanner retained ClinicalTrials.gov record NCT02078323 at 2026-07-30T21:10:02.997Z. Its registry update date was 2018-07-23, and PeptideScanner's reviewed identity mapping was linaclotide.↗
Added to PeptideScanner August 9, 2026Clinical trials
ClinicalTrials.gov record NCT00730171↗
PeptideScanner retained ClinicalTrials.gov record NCT00730171 at 2026-07-30T21:12:47.419Z. Its registry update date was 2018-02-19, and PeptideScanner's reviewed identity mapping was linaclotide.↗
Added to PeptideScanner August 9, 2026
Source year
2017
Literature metadata
Constella™(EU)-Linzess™(USA): the last milestone in the long journey of the peptide linaclotide and its implications for the future of peptide drugs.↗
PubMed lists PMID 23464519 in Future medicinal chemistry as Journal Article, Research Support, Non-U.S. Gov't, Review, with publication-date metadata of 2013-03 (month precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: March 2013 · month precisionAdded to PeptideScanner August 13, 2026Literature metadata
Linaclotide for constipation-predominant IBS.↗
PubMed lists PMID 24227771 in Drug and therapeutics bulletin as Journal Article, with publication-date metadata of 2013-11 (month precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: November 2013 · month precisionAdded to PeptideScanner August 13, 2026Literature metadata
Economic evaluation of linaclotide for the treatment of adult patients with irritable bowel syndrome with constipation in the United States.↗
PubMed lists PMID 25333331 in Journal of medical economics as Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2015-04 (month precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: April 2015 · month precisionAdded to PeptideScanner August 13, 2026Literature metadata
PubMed record PMID 17694454↗
PeptideScanner retained PubMed bibliographic metadata for PMID 17694454 at 2026-07-30T21:22:56.977Z. PubMed recorded a metadata revision date of 2017-11-16 and an Entrez history date of 2007-08-19. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Literature metadata
PubMed record PMID 19098860↗
PeptideScanner retained PubMed bibliographic metadata for PMID 19098860 at 2026-07-30T21:22:56.979Z. PubMed recorded a metadata revision date of 2017-11-16 and an Entrez history date of 2008-12-23. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Literature metadata
PubMed record PMID 19706070↗
PeptideScanner retained PubMed bibliographic metadata for PMID 19706070 at 2026-07-30T21:22:57.963Z. PubMed recorded a metadata revision date of 2017-11-16 and an Entrez history date of 2009-08-27. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Literature metadata
PubMed record PMID 20560145↗
PeptideScanner retained PubMed bibliographic metadata for PMID 20560145 at 2026-07-30T21:22:57.971Z. PubMed recorded a metadata revision date of 2017-11-16 and an Entrez history date of 2010-06-19. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Regulatory
Linaclotide DailyMed SPL version 17↗
DailyMed lists Structured Product Labeling version 17 for the reviewed Linaclotide label family with a published date of 2017-11-02. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Regulatory
Linaclotide DailyMed SPL version 16↗
DailyMed lists Structured Product Labeling version 16 for the reviewed Linaclotide label family with a published date of 2017-07-03. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Regulatory
Linaclotide DailyMed SPL version 15↗
DailyMed lists Structured Product Labeling version 15 for the reviewed Linaclotide label family with a published date of 2017-06-26. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Clinical trials
ClinicalTrials.gov record NCT02291679↗
PeptideScanner retained ClinicalTrials.gov record NCT02291679 at 2026-07-30T21:24:24.231Z. Its registry update date was 2017-06-15, and PeptideScanner's reviewed identity mapping was linaclotide.↗
Added to PeptideScanner August 9, 2026Regulatory
Linaclotide DailyMed SPL version 14↗
DailyMed lists Structured Product Labeling version 14 for the reviewed Linaclotide label family with a published date of 2017-06-08. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Regulatory
Linaclotide DailyMed SPL version 13↗
DailyMed lists Structured Product Labeling version 13 for the reviewed Linaclotide label family with a published date of 2017-02-15. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026
Source year
2016
Regulatory
Linaclotide DailyMed SPL version 12↗
DailyMed lists Structured Product Labeling version 12 for the reviewed Linaclotide label family with a published date of 2016-11-03. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Regulatory
Linaclotide DailyMed SPL version 11↗
DailyMed lists Structured Product Labeling version 11 for the reviewed Linaclotide label family with a published date of 2016-09-20. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Literature metadata
PubMed record PMID 27200765↗
PeptideScanner retained PubMed bibliographic metadata for PMID 27200765 at 2026-07-30T21:38:23.145Z. PubMed recorded a metadata revision date of 2016-05-21 and an Entrez history date of 2016-05-21. PeptideScanner associated this retained record with the identity slug linaclotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Regulatory
Linaclotide DailyMed SPL version 10↗
DailyMed lists Structured Product Labeling version 10 for the reviewed Linaclotide label family with a published date of 2016-04-18. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026
Source year
2015
Regulatory
Linaclotide DailyMed SPL version 9↗
DailyMed lists Structured Product Labeling version 9 for the reviewed Linaclotide label family with a published date of 2015-12-18. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Regulatory
Linaclotide DailyMed SPL version 8↗
DailyMed lists Structured Product Labeling version 8 for the reviewed Linaclotide label family with a published date of 2015-12-04. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026
Source year
2014
Regulatory
Linaclotide DailyMed SPL version 7↗
DailyMed lists Structured Product Labeling version 7 for the reviewed Linaclotide label family with a published date of 2014-07-17. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Regulatory
Linaclotide DailyMed SPL version 6↗
DailyMed lists Structured Product Labeling version 6 for the reviewed Linaclotide label family with a published date of 2014-07-16. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Regulatory
Federal Register notice 2014-11926↗
The Federal Register published notice 2014-11926, attributed to FDA and its parent HHS department, on 2014-05-23. Its official title is “Determination of Regulatory Review Period for Purposes of Patent Extension; LINZESS,” and PeptideScanner's exact reviewed identity mapping connects the document to Linaclotide.↗
Added to PeptideScanner August 21, 2026
Source year
2013
Regulatory
Linaclotide DailyMed SPL version 5↗
DailyMed lists Structured Product Labeling version 5 for the reviewed Linaclotide label family with a published date of 2013-08-06. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Regulatory
Linaclotide DailyMed SPL version 4↗
DailyMed lists Structured Product Labeling version 4 for the reviewed Linaclotide label family with a published date of 2013-04-12. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Clinical trials
ClinicalTrials.gov record NCT00730015↗
PeptideScanner retained ClinicalTrials.gov record NCT00730015 at 2026-07-30T21:55:56.622Z. Its registry update date was 2013-01-30, and PeptideScanner's reviewed identity mapping was linaclotide.↗
Added to PeptideScanner August 9, 2026
Source year
2012
Regulatory
Linaclotide DailyMed SPL version 2↗
DailyMed lists Structured Product Labeling version 2 for the reviewed Linaclotide label family with a published date of 2012-09-11. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Regulatory
Drugs@FDA application NDA202811↗
The official Drugs@FDA dataset lists original submission 1 for NDA 202811 with status AP dated 2012-08-30, and names linaclotide among the application record's active ingredients.↗
Added to PeptideScanner August 14, 2026