Two selected reports examine a long-acting, albumin-binding CJC-1295 preparation in healthy adults. Hormone measurements are distinct from patient benefit, and findings should not be transferred to differently identified preparations.12
Bottom line from this bounded source set
The studies reported sustained growth hormone and IGF-I responses, including preserved hormone pulsatility. They do not establish clinical benefit for injury recovery, body composition or aging, or long-term safety.12
Reviewed study record
Early pharmacology trials in healthy adults
Design
Two blinded randomized placebo-controlled studies assessed pharmacokinetics and hormone responses over 28 and 49 days.1
Population
Participants were healthy adults aged 21–61; the abstract does not state their total number.1
Outcomes reported
Growth hormone and IGF-I concentrations increased for several days. The report recorded no serious adverse reactions.1
Limitations
Short-term hormone changes are surrogate measurements. No serious reactions in these studies does not establish safety over longer exposure or in other populations.1
Reviewed study record
Growth-hormone pulsatility
Design
A before-and-after physiology study measured overnight hormone secretion before and one week after exposure.2
Population
The participants were healthy men aged 20–40; the abstract does not state their total number.2
Outcomes reported
Mean and trough growth hormone levels and IGF-I increased, while pulse frequency and magnitude were unchanged.2
Limitations
The report describes an albumin-binding preparation and physiological endpoints. It does not establish improvement in a clinical condition or comparative long-term safety.2
No registered Crossref update in the reviewed snapshotChecked September 15, 2026 for DOI 10.1210/jc.2005-1536. This bounded result is not proof that the publication has never been corrected or retracted. Open the pinned Crossref work endpoint ↗
No registered Crossref update in the reviewed snapshotChecked September 15, 2026 for DOI 10.1210/jc.2006-1702. This bounded result is not proof that the publication has never been corrected or retracted. Open the pinned Crossref work endpoint ↗