Profile change history

What changed for Semax?

A deterministic history of records added to PeptideScanner and preserved profile or record revisions connected through the reviewed Semax identity.

43Total events
42Record additions
1Version changes
11Cited source years

Before and after

Preserved version changes

Correction

Semax profile

We narrowed the status wording to what the dated FDA briefing establishes. A briefing prepared for an advisory process does not establish the current absence of a later final decision. Related substance identities remain distinct.

PeptideScanner change date
September 15, 2026
Evidence lane
Profile

Status

Before
FDA compounding safety review; final determination pending
After
FDA compounding assessment in the cited records

Evidence note

Before
FDA's Semax briefing describes evidence and safety questions presented to the advisory committee. Committee recommendations are nonbinding, and FDA says its final determination will follow completion of the committee process and relevant reviews.
After
FDA's July 2026 briefing evaluates Semax-related bulk drug substances for pharmacy compounding. The briefing is an advisory-process assessment, not a final regulatory determination.

Claim citations

Before
name: fda-semax-briefing; aliases: fda-semax-briefing; category: fda-semax-briefing, fda-pcac-peptide-meeting-2026; status: fda-semax-briefing, fda-pcac-peptide-meeting-2026; summary: fda-semax-briefing, fda-pcac-peptide-meeting-2026; evidenceNote: fda-semax-briefing, fda-pcac-peptide-meeting-2026
After
name: fda-semax-briefing; aliases: fda-semax-briefing; category: fda-semax-briefing, fda-pcac-peptide-meeting-2026; status: fda-semax-briefing; summary: fda-semax-briefing, fda-pcac-peptide-meeting-2026; evidenceNote: fda-semax-briefing

Collection chronology

Evidence added to PeptideScanner

Browse all 42 connected records →

Showing the latest 42 additions by PeptideScanner publication date; the complete connected record set remains available in Latest Research. Most recent addition: August 21, 2026.

Record added

Federal Register notice 2026-07361

The Federal Register published notice 2026-07361, attributed to FDA and its parent HHS department, on 2026-04-16. Its official title is “Pharmacy Compounding Advisory Committee; Notice of Meeting; Establishment of a Public Docket; Request for Comments-Bulk Drug Substances Nominated for Inclusion on the Section 503A Bulk Drug Substances List,” and PeptideScanner's exact reviewed identity mapping connects the document to BPC-157, Emideltide, Epitalon, KPV, MOTS-c, Semax and TB-500.

PeptideScanner change date
August 21, 2026
Cited source date
April 16, 2026
Evidence lane
Regulatory
Record added

Study on the neurotropic activity of the products of Semax enzymatic degradation.

PubMed lists PMID 10944712 in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections as Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2000 May-Jun (source-text precision). PeptideScanner associated the retained record with the identity slug semax. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
November 24, 2016
Evidence lane
Literature metadata
Record added

[New regulatory peptides in rat stomach secretion (amylin, PGP, semax)].

PubMed lists PMID 12875006 in Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology as Journal Article, with publication-date metadata of 2003 (year precision). PeptideScanner associated the retained record with the identity slug semax. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
November 30, 2018
Evidence lane
Literature metadata
Record added

[The binding of Semax, ACTH 4-10 heptapeptide, to plasma membranes of the rat forebrain basal nuclei and its biodegradation].

PubMed lists PMID 15344653 in Bioorganicheskaia khimiia as English Abstract, Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2004 May-Jun (source-text precision). PeptideScanner associated the retained record with the identity slug semax. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
October 26, 2019
Evidence lane
Literature metadata
Record added

[Kinetics of Semax penetration into the brain and blood of rats after its intranasal administration].

PubMed lists PMID 16523722 in Bioorganicheskaia khimiia as English Abstract, Journal Article, with publication-date metadata of 2006 Jan-Feb (source-text precision). PeptideScanner associated the retained record with the identity slug semax. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
October 26, 2019
Evidence lane
Literature metadata
Record added

Degradation of the ACTH(4-10) analog Semax in the presence of rat basal forebrain cell cultures and plasma membranes.

PubMed lists PMID 16773243 in Amino acids as Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2006-05-26 (day precision). PeptideScanner associated the retained record with the identity slug semax. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
November 24, 2016
Evidence lane
Literature metadata
Record added

Specific binding of semax in different regions of the rat brain.

PubMed lists PMID 17278839 in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections as Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2006 Sep-Oct (source-text precision). PeptideScanner associated the retained record with the identity slug semax. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
September 22, 2019
Evidence lane
Literature metadata
Record added

Comparative study of analgesic potency of ACTH4-10 fragment and its analog semax.

PubMed lists PMID 18018999 in Bulletin of experimental biology and medicine as Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2007-01 (month precision). PeptideScanner associated the retained record with the identity slug semax. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
August 13, 2019
Evidence lane
Literature metadata
Record added

Therapeutic possibility of "Semax" for depression.

PubMed lists PMID 18204410 in CNS spectrums as Letter, Research Support, Non-U.S. Gov't, with publication-date metadata of 2008-01 (month precision). PeptideScanner associated the retained record with the identity slug semax. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
January 28, 2026
Evidence lane
Literature metadata
Record added

N-terminal degradation of ACTH(4-10) and its synthetic analog semax by the rat blood enzymes.

PubMed lists PMID 1851003 in Biochemical and biophysical research communications as Journal Article, with publication-date metadata of 1991-04-30 (day precision). PeptideScanner associated the retained record with the identity slug semax. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
June 12, 2019
Evidence lane
Literature metadata
Record added

Audiogenic epilepsy in young mice of different strains after neonatal semax treatment.

PubMed lists PMID 19145359 in Bulletin of experimental biology and medicine as Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2008-07 (month precision). PeptideScanner associated the retained record with the identity slug semax. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
August 13, 2019
Evidence lane
Literature metadata
Record added

[Proteolysis of semax analogues with different N-terminal amino acids by aminopeptidases].

PubMed lists PMID 22096989 in Bioorganicheskaia khimiia as Journal Article, with publication-date metadata of 2011 Jul-Aug (source-text precision). PeptideScanner associated the retained record with the identity slug semax. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
October 27, 2019
Evidence lane
Literature metadata
Record added

Stability of Semax acetyl to proteolysis in various biological media.

PubMed lists PMID 23652441 in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections as Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2013-05-08 (day precision). PeptideScanner associated the retained record with the identity slug semax. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
October 21, 2021
Evidence lane
Literature metadata
Record added

Study of proteolysis of Semax analogues with different N-terminal amino acids by carboxypeptidases.

PubMed lists PMID 23821053 in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections as Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2013-07-03 (day precision). PeptideScanner associated the retained record with the identity slug semax. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
October 21, 2021
Evidence lane
Literature metadata
Record added

Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties.

PubMed lists PMID 27586814 in Journal of inorganic biochemistry as Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2016-08-27 (day precision). PeptideScanner associated the retained record with the identity slug semax. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
March 12, 2018
Evidence lane
Literature metadata
Record added

Influence of ACTG4-7-PGP (Semax) on Morphofunctional State of Hepatocytes in Chronic Emotional and Painful Stress.

PubMed lists PMID 28577097 in Bulletin of experimental biology and medicine as Journal Article, with publication-date metadata of 2017-06-03 (day precision). PeptideScanner associated the retained record with the identity slug semax. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
March 19, 2018
Evidence lane
Literature metadata
Record added

Composition of Colon Microbiota in Rats Treated with ACTH(4-7)-PGP Peptide (Semax) under Conditions of Restraint Stress.

PubMed lists PMID 32737723 in Bulletin of experimental biology and medicine as Journal Article, with publication-date metadata of 2020-08-01 (day precision). PeptideScanner associated the retained record with the identity slug semax. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
June 7, 2021
Evidence lane
Literature metadata
Record added

PubMed record PMID 11188738

PeptideScanner retained PubMed bibliographic metadata for PMID 11188738 at 2026-07-30T22:38:13.871Z. PubMed recorded a metadata revision date of 2008-10-08 and an Entrez history date of 2001-02-24. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
October 8, 2008
Evidence lane
Literature metadata
Record added

PubMed record PMID 11548444

PeptideScanner retained PubMed bibliographic metadata for PMID 11548444 at 2026-07-30T21:56:55.056Z. PubMed recorded a metadata revision date of 2013-11-21 and an Entrez history date of 2001-09-11. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
November 21, 2013
Evidence lane
Literature metadata
Record added

PubMed record PMID 11569188

PeptideScanner retained PubMed bibliographic metadata for PMID 11569188 at 2026-07-30T22:26:16.761Z. PubMed recorded a metadata revision date of 2010-11-18 and an Entrez history date of 2001-09-25. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
November 18, 2010
Evidence lane
Literature metadata
Record added

PubMed record PMID 14653248

PeptideScanner retained PubMed bibliographic metadata for PMID 14653248 at 2026-07-30T21:56:55.927Z. PubMed recorded a metadata revision date of 2013-11-21 and an Entrez history date of 2003-12-05. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
November 21, 2013
Evidence lane
Literature metadata
Record added

PubMed record PMID 15188751

PeptideScanner retained PubMed bibliographic metadata for PMID 15188751 at 2026-07-30T21:56:56.690Z. PubMed recorded a metadata revision date of 2013-11-21 and an Entrez history date of 2004-06-11. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
November 21, 2013
Evidence lane
Literature metadata
Record added

PubMed record PMID 16635254

PeptideScanner retained PubMed bibliographic metadata for PMID 16635254 at 2026-07-30T21:56:57.667Z. PubMed recorded a metadata revision date of 2013-11-21 and an Entrez history date of 2006-04-26. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
November 21, 2013
Evidence lane
Literature metadata
Record added

PubMed record PMID 18431004

PeptideScanner retained PubMed bibliographic metadata for PMID 18431004 at 2026-07-30T22:38:13.909Z. PubMed recorded a metadata revision date of 2008-04-23 and an Entrez history date of 2008-04-24. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
April 23, 2008
Evidence lane
Literature metadata
Record added

PubMed record PMID 18488900

PeptideScanner retained PubMed bibliographic metadata for PMID 18488900 at 2026-07-30T22:38:13.911Z. PubMed recorded a metadata revision date of 2008-05-20 and an Entrez history date of 2008-05-21. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
May 20, 2008
Evidence lane
Literature metadata
Record added

PubMed record PMID 18756821

PeptideScanner retained PubMed bibliographic metadata for PMID 18756821 at 2026-07-30T22:38:13.932Z. PubMed recorded a metadata revision date of 2008-09-01 and an Entrez history date of 2008-09-02. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
September 1, 2008
Evidence lane
Literature metadata
Record added

PubMed record PMID 19441725

PeptideScanner retained PubMed bibliographic metadata for PMID 19441725 at 2026-07-30T22:27:39.905Z. PubMed recorded a metadata revision date of 2009-05-15 and an Entrez history date of 2009-05-16. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
May 15, 2009
Evidence lane
Literature metadata
Record added

PubMed record PMID 22295573

PeptideScanner retained PubMed bibliographic metadata for PMID 22295573 at 2026-07-30T21:57:00.518Z. PubMed recorded a metadata revision date of 2013-11-21 and an Entrez history date of 2012-02-03. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
November 21, 2013
Evidence lane
Literature metadata
Record added

PubMed record PMID 23072114

PeptideScanner retained PubMed bibliographic metadata for PMID 23072114 at 2026-07-30T21:57:01.392Z. PubMed recorded a metadata revision date of 2013-11-21 and an Entrez history date of 2012-10-18. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
November 21, 2013
Evidence lane
Literature metadata
Record added

PubMed record PMID 8679991

PeptideScanner retained PubMed bibliographic metadata for PMID 8679991 at 2026-07-30T22:38:13.862Z. PubMed recorded a metadata revision date of 2008-10-08 and an Entrez history date of 1996-01-01. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
October 8, 2008
Evidence lane
Literature metadata
Record added

PubMed record PMID 8998343

PeptideScanner retained PubMed bibliographic metadata for PMID 8998343 at 2026-07-30T22:38:13.864Z. PubMed recorded a metadata revision date of 2008-10-08 and an Entrez history date of 1996-11-01. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
October 8, 2008
Evidence lane
Literature metadata
Record added

PubMed record PMID 9303728

PeptideScanner retained PubMed bibliographic metadata for PMID 9303728 at 2026-07-30T22:38:13.866Z. PubMed recorded a metadata revision date of 2008-10-08 and an Entrez history date of 1997-07-01. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
October 8, 2008
Evidence lane
Literature metadata
Record added

PubMed record PMID 9606550

PeptideScanner retained PubMed bibliographic metadata for PMID 9606550 at 2026-07-30T22:38:13.868Z. PubMed recorded a metadata revision date of 2008-10-08 and an Entrez history date of 1998-06-02. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
October 8, 2008
Evidence lane
Literature metadata
Record added

PubMed record PMID 11548604

PeptideScanner retained PubMed bibliographic metadata for PMID 11548604 at 2026-07-30T22:50:21.632Z. PubMed recorded a metadata revision date of 2006-11-15 and an Entrez history date of 2001-09-11. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 11, 2026
Cited source date
November 15, 2006
Evidence lane
Literature metadata
Record added

PubMed record PMID 15678666

PeptideScanner retained PubMed bibliographic metadata for PMID 15678666 at 2026-07-30T22:50:21.662Z. PubMed recorded a metadata revision date of 2006-11-15 and an Entrez history date of 2005-02-01. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 11, 2026
Cited source date
November 15, 2006
Evidence lane
Literature metadata
Record added

PubMed record PMID 15895862

PeptideScanner retained PubMed bibliographic metadata for PMID 15895862 at 2026-07-30T22:50:21.664Z. PubMed recorded a metadata revision date of 2006-11-15 and an Entrez history date of 2005-05-18. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 11, 2026
Cited source date
November 15, 2006
Evidence lane
Literature metadata
Record added

PubMed record PMID 16996699

PeptideScanner retained PubMed bibliographic metadata for PMID 16996699 at 2026-07-30T22:40:22.965Z. PubMed recorded a metadata revision date of 2007-02-23 and an Entrez history date of 2006-09-26. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 11, 2026
Cited source date
February 23, 2007
Evidence lane
Literature metadata
Record added

PubMed record PMID 10498989

PeptideScanner retained PubMed bibliographic metadata for PMID 10498989 at 2026-07-30T22:50:21.627Z. PubMed recorded a metadata revision date of 2006-11-15 and an Entrez history date of 1999-09-28. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 10, 2026
Cited source date
November 15, 2006
Evidence lane
Literature metadata
Record added

PubMed record PMID 10741256

PeptideScanner retained PubMed bibliographic metadata for PMID 10741256 at 2026-07-30T22:50:21.628Z. PubMed recorded a metadata revision date of 2006-11-15 and an Entrez history date of 2000-03-31. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 10, 2026
Cited source date
November 15, 2006
Evidence lane
Literature metadata
Record added

PubMed record PMID 11177268

PeptideScanner retained PubMed bibliographic metadata for PMID 11177268 at 2026-07-30T22:50:21.630Z. PubMed recorded a metadata revision date of 2006-11-15 and an Entrez history date of 2001-02-15. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 10, 2026
Cited source date
November 15, 2006
Evidence lane
Literature metadata
Record added

PubMed record PMID 11202510

PeptideScanner retained PubMed bibliographic metadata for PMID 11202510 at 2026-07-30T22:50:21.630Z. PubMed recorded a metadata revision date of 2006-11-15 and an Entrez history date of 2001-02-24. PeptideScanner associated this retained record with the identity slug semax. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 10, 2026
Cited source date
November 15, 2006
Evidence lane
Literature metadata
Record added

FDA committee met on seven peptide-related groups of bulk drug substances

FDA convened its Pharmacy Compounding Advisory Committee on July 23-24, 2026, to discuss free-base and acetate bulk drug substances across seven peptide-related groups.

PeptideScanner change date
July 29, 2026
Cited source date
July 24, 2026
Evidence lane
Regulatory