Profile change history

What changed for MOTS-c?

A deterministic history of records added to PeptideScanner and preserved profile or record revisions connected through the reviewed MOTS-c identity.

44Total events
43Record additions
1Version changes
6Cited source years

Before and after

Preserved version changes

Profile updated

MOTS-c profile

We added FDA's dedicated briefing and advisory-committee meeting record, while preserving the pending and nonbinding nature of the review.

PeptideScanner change date
July 29, 2026
Evidence lane
Profile

Profile summary

Before
A mitochondrial-derived peptide included in an FDA compounding-risk record.
After
A mitochondrial-derived peptide represented in FDA compounding-risk and advisory-committee records.

Evidence note

Before
FDA's compounding-risk page says it has not identified human exposure data for drug products containing MOTS-c and lacks important safety information.
After
FDA presented MOTS-c briefing material at its July 2026 pharmacy-compounding advisory-committee meeting. Committee recommendations are nonbinding, and FDA says its final determination will follow completion of the committee process and relevant reviews.

Cited source records

Before
fda-bulk-peptide-risks
After
fda-bulk-peptide-risks, fda-mots-c-briefing, fda-pcac-peptide-meeting-2026

Named organizations

Before
U.S. Food and Drug Administration [sources: fda-bulk-peptide-risks]
After
U.S. Food and Drug Administration [sources: fda-bulk-peptide-risks, fda-mots-c-briefing, fda-pcac-peptide-meeting-2026]

Claim citations

Before
name: fda-bulk-peptide-risks; aliases: fda-bulk-peptide-risks; category: fda-bulk-peptide-risks; status: fda-bulk-peptide-risks; summary: fda-bulk-peptide-risks; evidenceNote: fda-bulk-peptide-risks
After
name: fda-mots-c-briefing; aliases: fda-mots-c-briefing; category: fda-bulk-peptide-risks, fda-mots-c-briefing; status: fda-mots-c-briefing, fda-pcac-peptide-meeting-2026; summary: fda-bulk-peptide-risks, fda-mots-c-briefing, fda-pcac-peptide-meeting-2026; evidenceNote: fda-mots-c-briefing, fda-pcac-peptide-meeting-2026

Collection chronology

Evidence added to PeptideScanner

Browse all 43 connected records →

Showing the latest 43 additions by PeptideScanner publication date; the complete connected record set remains available in Latest Research. Most recent addition: August 21, 2026.

Record added

Federal Register notice 2026-07361

The Federal Register published notice 2026-07361, attributed to FDA and its parent HHS department, on 2026-04-16. Its official title is “Pharmacy Compounding Advisory Committee; Notice of Meeting; Establishment of a Public Docket; Request for Comments-Bulk Drug Substances Nominated for Inclusion on the Section 503A Bulk Drug Substances List,” and PeptideScanner's exact reviewed identity mapping connects the document to BPC-157, Emideltide, Epitalon, KPV, MOTS-c, Semax and TB-500.

PeptideScanner change date
August 21, 2026
Cited source date
April 16, 2026
Evidence lane
Regulatory
Record added

The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?

PubMed lists PMID 26289118 in Aging cell as Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2015-08-20 (day precision). PeptideScanner associated the retained record with the identity slug mots-c. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
December 7, 2022
Evidence lane
Literature metadata
Record added

Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction.

PubMed lists PMID 29242099 in International journal of cardiology as Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2017-12-06 (day precision). PeptideScanner associated the retained record with the identity slug mots-c. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
October 11, 2024
Evidence lane
Literature metadata
Record added

MOTS-c: an equal opportunity insulin sensitizer.

PubMed lists PMID 30788534 in Journal of molecular medicine (Berlin, Germany) as Letter, Research Support, Non-U.S. Gov't, with publication-date metadata of 2019-02-20 (day precision). PeptideScanner associated the retained record with the identity slug mots-c. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
October 1, 2025
Evidence lane
Literature metadata
Record added

A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome.

PubMed lists PMID 31088495 in Journal of translational medicine as Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2019-05-14 (day precision). PeptideScanner associated the retained record with the identity slug mots-c. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
June 15, 2020
Evidence lane
Literature metadata
Record added

A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c.

PubMed lists PMID 33468709 in Aging as Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2021-01-19 (day precision). PeptideScanner associated the retained record with the identity slug mots-c. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
October 1, 2025
Evidence lane
Literature metadata
Record added

Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c).

PubMed lists PMID 35656563 in Diabetes & metabolism journal as Journal Article, Review, Research Support, Non-U.S. Gov't, with publication-date metadata of 2022-05-25 (day precision). PeptideScanner associated the retained record with the identity slug mots-c. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
February 4, 2026
Evidence lane
Literature metadata
Record added

MOTS-c as a predictor of coronary lesions and complexity in patients with stable coronary artery disease.

PubMed lists PMID 36066139 in European review for medical and pharmacological sciences as Journal Article, with publication-date metadata of 2022-08 (month precision). PeptideScanner associated the retained record with the identity slug mots-c. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
July 28, 2025
Evidence lane
Literature metadata
Record added

MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases.

PubMed lists PMID 36233287 in International journal of molecular sciences as Journal Article, Review, with publication-date metadata of 2022-10-09 (day precision). PeptideScanner associated the retained record with the identity slug mots-c. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
October 19, 2022
Evidence lane
Literature metadata
Record added

Circulating levels of MOTS-c in patients with breast cancer treated with metformin.

PubMed lists PMID 36490309 in Aging as Randomized Controlled Trial, Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2022-12-06 (day precision). PeptideScanner associated the retained record with the identity slug mots-c. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
January 27, 2026
Evidence lane
Literature metadata
Record added

Evaluation of Serum Humanin and MOTS-c Peptide Levels in Patients with COVID-19 and Healthy Subjects.

PubMed lists PMID 36799414 in Current protein & peptide science as Journal Article, with publication-date metadata of 2023 (year precision). PeptideScanner associated the retained record with the identity slug mots-c. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
January 27, 2026
Evidence lane
Literature metadata
Record added

Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases.

PubMed lists PMID 36824008 in Diabetes & metabolism journal as Journal Article, Review, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, with publication-date metadata of 2023-02-24 (day precision). PeptideScanner associated the retained record with the identity slug mots-c. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
June 10, 2023
Evidence lane
Literature metadata
Record added

Circulating levels of mitochondrial oxidative stress-related peptides MOTS-c and Romo1 in stable COPD: A cross-sectional study.

PubMed lists PMID 36844198 in Frontiers in medicine as Journal Article, with publication-date metadata of 2023-02-08 (day precision). PeptideScanner associated the retained record with the identity slug mots-c. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
February 28, 2023
Evidence lane
Literature metadata
Record added

Central MOTS-c infusion affects reproductive hormones in obese and non-obese rats.

PubMed lists PMID 38462167 in Neuroscience letters as Journal Article, with publication-date metadata of 2024-03-08 (day precision). PeptideScanner associated the retained record with the identity slug mots-c. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
April 1, 2024
Evidence lane
Literature metadata
Record added

Mitochondria-encoded peptide MOTS-c participates in plasma membrane repair by facilitating the translocation of TRIM72 to membrane.

PubMed lists PMID 39267782 in Theranostics as Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2024-08-19 (day precision). PeptideScanner associated the retained record with the identity slug mots-c. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
June 5, 2025
Evidence lane
Literature metadata
Record added

Serum MOTS-c levels remain unchanged in patients with preeclampsia.

PubMed lists PMID 39469962 in Ginekologia polska as Journal Article, with publication-date metadata of 2023 (year precision). PeptideScanner associated the retained record with the identity slug mots-c. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
October 29, 2024
Evidence lane
Literature metadata
Record added

Evaluation of vascular peroxidase 1, humanin, MOTS-c and miR-200c expression levels in untreated preeclampsia patients.

PubMed lists PMID 39704971 in Molecular biology reports as Journal Article, with publication-date metadata of 2024-12-20 (day precision). PeptideScanner associated the retained record with the identity slug mots-c. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
January 27, 2026
Evidence lane
Literature metadata
Record added

Could MOTS-c Levels in Children with Type 1 Diabetes Mellitus Be an Indicator for Early Diabetic Kidney Disease?

PubMed lists PMID 39711006 in Journal of clinical research in pediatric endocrinology as Journal Article, with publication-date metadata of 2024-12-23 (day precision). PeptideScanner associated the retained record with the identity slug mots-c. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
May 31, 2025
Evidence lane
Literature metadata
Record added

PubMed record PMID 40035775

PeptideScanner retained PubMed bibliographic metadata for PMID 40035775 at 2026-07-30T16:14:10.913Z. PubMed recorded a metadata revision date of 2026-06-22 and an Entrez history date of 2025-03-04. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 22, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 40072017

PeptideScanner retained PubMed bibliographic metadata for PMID 40072017 at 2026-07-30T16:14:10.926Z. PubMed recorded a metadata revision date of 2026-06-22 and an Entrez history date of 2025-03-12. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 22, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 40246631

PeptideScanner retained PubMed bibliographic metadata for PMID 40246631 at 2026-07-30T16:14:10.971Z. PubMed recorded a metadata revision date of 2026-06-09 and an Entrez history date of 2025-04-17. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 9, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 41520850

PeptideScanner retained PubMed bibliographic metadata for PMID 41520850 at 2026-07-30T16:14:14.728Z. PubMed recorded a metadata revision date of 2026-06-26 and an Entrez history date of 2026-01-11. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 26, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 41654147

PeptideScanner retained PubMed bibliographic metadata for PMID 41654147 at 2026-08-10T18:13:40.626Z. PubMed recorded a metadata revision date of 2026-07-07 and an Entrez history date of 2026-02-07. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
July 7, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 41680431

PeptideScanner retained PubMed bibliographic metadata for PMID 41680431 at 2026-07-30T16:14:14.846Z. PubMed recorded a metadata revision date of 2026-06-27 and an Entrez history date of 2026-02-12. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 27, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 41706383

PeptideScanner retained PubMed bibliographic metadata for PMID 41706383 at 2026-08-10T18:13:42.683Z. PubMed recorded a metadata revision date of 2026-07-08 and an Entrez history date of 2026-02-18. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
July 8, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 41710402

PeptideScanner retained PubMed bibliographic metadata for PMID 41710402 at 2026-08-10T18:13:42.691Z. PubMed recorded a metadata revision date of 2026-07-08 and an Entrez history date of 2026-02-19. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
July 8, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 41732124

PeptideScanner retained PubMed bibliographic metadata for PMID 41732124 at 2026-08-10T18:13:42.721Z. PubMed recorded a metadata revision date of 2026-07-08 and an Entrez history date of 2026-02-24. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
July 8, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 41764620

PeptideScanner retained PubMed bibliographic metadata for PMID 41764620 at 2026-08-10T18:13:42.760Z. PubMed recorded a metadata revision date of 2026-07-10 and an Entrez history date of 2026-03-01. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
July 10, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42142418

PeptideScanner retained PubMed bibliographic metadata for PMID 42142418 at 2026-07-30T16:14:16.748Z. PubMed recorded a metadata revision date of 2026-06-12 and an Entrez history date of 2026-05-16. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 12, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42153537

PeptideScanner retained PubMed bibliographic metadata for PMID 42153537 at 2026-07-30T16:14:16.751Z. PubMed recorded a metadata revision date of 2026-06-02 and an Entrez history date of 2026-05-19. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 2, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42228044

PeptideScanner retained PubMed bibliographic metadata for PMID 42228044 at 2026-07-30T16:14:18.046Z. PubMed recorded a metadata revision date of 2026-06-04 and an Entrez history date of 2026-06-02. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 4, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42243958

PeptideScanner retained PubMed bibliographic metadata for PMID 42243958 at 2026-08-12T11:06:05.213Z. PubMed recorded a metadata revision date of 2026-08-12 and an Entrez history date of 2026-06-05. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
August 12, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42266945

PeptideScanner retained PubMed bibliographic metadata for PMID 42266945 at 2026-07-30T16:14:18.139Z. PubMed recorded a metadata revision date of 2026-06-10 and an Entrez history date of 2026-06-10. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 10, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42324588

PeptideScanner retained PubMed bibliographic metadata for PMID 42324588 at 2026-07-30T16:14:19.320Z. PubMed recorded a metadata revision date of 2026-06-21 and an Entrez history date of 2026-06-21. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 21, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 41593376

PeptideScanner retained PubMed bibliographic metadata for PMID 41593376 at 2026-08-10T18:13:40.572Z. PubMed recorded a metadata revision date of 2026-07-13 and an Entrez history date of 2026-01-27. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 11, 2026
Cited source date
July 13, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 41802484

PeptideScanner retained PubMed bibliographic metadata for PMID 41802484 at 2026-08-10T18:13:44.802Z. PubMed recorded a metadata revision date of 2026-07-10 and an Entrez history date of 2026-03-09. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 11, 2026
Cited source date
July 10, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 41811086

PeptideScanner retained PubMed bibliographic metadata for PMID 41811086 at 2026-08-10T18:13:44.817Z. PubMed recorded a metadata revision date of 2026-07-10 and an Entrez history date of 2026-03-11. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 11, 2026
Cited source date
July 10, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 41933740

PeptideScanner retained PubMed bibliographic metadata for PMID 41933740 at 2026-08-10T18:13:46.811Z. PubMed recorded a metadata revision date of 2026-07-14 and an Entrez history date of 2026-04-04. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 11, 2026
Cited source date
July 14, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 41945630

PeptideScanner retained PubMed bibliographic metadata for PMID 41945630 at 2026-08-10T18:13:46.825Z. PubMed recorded a metadata revision date of 2026-07-14 and an Entrez history date of 2026-04-07. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 10, 2026
Cited source date
July 14, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42128272

PeptideScanner retained PubMed bibliographic metadata for PMID 42128272 at 2026-08-10T18:13:50.589Z. PubMed recorded a metadata revision date of 2026-07-16 and an Entrez history date of 2026-05-13. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 10, 2026
Cited source date
July 16, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42278864

PeptideScanner retained PubMed bibliographic metadata for PMID 42278864 at 2026-08-10T18:13:52.251Z. PubMed recorded a metadata revision date of 2026-07-26 and an Entrez history date of 2026-06-12. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 10, 2026
Cited source date
July 26, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42321010

PeptideScanner retained PubMed bibliographic metadata for PMID 42321010 at 2026-08-10T10:49:10.706Z. PubMed recorded a metadata revision date of 2026-07-30 and an Entrez history date of 2026-06-19. PeptideScanner associated this retained record with the identity slug mots-c. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 10, 2026
Cited source date
July 30, 2026
Evidence lane
Literature metadata
Record added

FDA committee met on seven peptide-related groups of bulk drug substances

FDA convened its Pharmacy Compounding Advisory Committee on July 23-24, 2026, to discuss free-base and acetate bulk drug substances across seven peptide-related groups.

PeptideScanner change date
July 29, 2026
Cited source date
July 24, 2026
Evidence lane
Regulatory