Cross-source evidence timeline

Lixisenatide research timeline

Follow 64 selected, directly cited source records from December 15, 2015 through July 30, 2026. This timeline joins source lanes for navigation; it does not infer that one record confirms another.

64Selected records
12Source years
3Evidence lanes
July 30, 2026Latest source date

Source year

2026

22 records
Literature metadata · 21Regulatory · 1
  1. Literature metadata

    PubMed record PMID 39604042↗

    PeptideScanner retained PubMed bibliographic metadata for PMID 39604042 at 2026-07-30T16:31:16.748Z. PubMed recorded a metadata revision date of 2026-07-30 and an Entrez history date of 2024-11-27. PeptideScanner associated this retained record with the identity slug lixisenatide. These dates describe PubMed metadata history, not the article's original publication date.↗

  2. Literature metadata

    PubMed record PMID 38870730↗

    PeptideScanner retained PubMed bibliographic metadata for PMID 38870730 at 2026-08-10T18:13:32.367Z. PubMed recorded a metadata revision date of 2026-07-02 and an Entrez history date of 2024-06-13. PeptideScanner associated this retained record with the identity slug lixisenatide. These dates describe PubMed metadata history, not the article's original publication date.↗

  3. Literature metadata

    PubMed record PMID 38685598↗

    PeptideScanner retained PubMed bibliographic metadata for PMID 38685598 at 2026-07-30T16:14:06.932Z. PubMed recorded a metadata revision date of 2026-06-18 and an Entrez history date of 2024-04-30. PeptideScanner associated this retained record with the identity slug lixisenatide. These dates describe PubMed metadata history, not the article's original publication date.↗

  4. Literature metadata

    PubMed record PMID 38877681↗

    PeptideScanner retained PubMed bibliographic metadata for PMID 38877681 at 2026-07-30T16:20:38.897Z. PubMed recorded a metadata revision date of 2026-05-31 and an Entrez history date of 2024-06-15. PeptideScanner associated this retained record with the identity slug lixisenatide. These dates describe PubMed metadata history, not the article's original publication date.↗

  5. Literature metadata

    PubMed record PMID 39407425↗

    PeptideScanner retained PubMed bibliographic metadata for PMID 39407425 at 2026-07-30T16:20:39.038Z. PubMed recorded a metadata revision date of 2026-05-31 and an Entrez history date of 2024-10-16. PeptideScanner associated this retained record with the identity slug lixisenatide. These dates describe PubMed metadata history, not the article's original publication date.↗

  6. Literature metadata

    PubMed record PMID 22564709↗

    PeptideScanner retained PubMed bibliographic metadata for PMID 22564709 at 2026-07-30T16:20:34.419Z. PubMed recorded a metadata revision date of 2026-05-18 and an Entrez history date of 2012-05-09. PeptideScanner associated this retained record with the identity slug lixisenatide. These dates describe PubMed metadata history, not the article's original publication date.↗

  7. Literature metadata

    PubMed record PMID 39157869↗

    PeptideScanner retained PubMed bibliographic metadata for PMID 39157869 at 2026-07-30T16:23:36.341Z. PubMed recorded a metadata revision date of 2026-03-23 and an Entrez history date of 2024-08-19. PeptideScanner associated this retained record with the identity slug lixisenatide. These dates describe PubMed metadata history, not the article's original publication date.↗

  8. Regulatory

    Lixisenatide DailyMed SPL version 25↗

    DailyMed lists Structured Product Labeling version 25 for the reviewed Lixisenatide label family with a published date of 2026-03-20. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗

  9. Literature metadata

    PubMed record PMID 41623754↗

    PeptideScanner retained PubMed bibliographic metadata for PMID 41623754 at 2026-07-30T16:25:14.225Z. PubMed recorded a metadata revision date of 2026-02-04 and an Entrez history date of 2026-02-02. PeptideScanner associated this retained record with the identity slug lixisenatide. These dates describe PubMed metadata history, not the article's original publication date.↗

  10. Literature metadata

    PubMed record PMID 25012990↗

    PeptideScanner retained PubMed bibliographic metadata for PMID 25012990 at 2026-07-30T16:30:52.644Z. PubMed recorded a metadata revision date of 2026-01-28 and an Entrez history date of 2014-07-12. PeptideScanner associated this retained record with the identity slug lixisenatide. These dates describe PubMed metadata history, not the article's original publication date.↗

  11. Literature metadata

    PubMed record PMID 25055456↗

    PeptideScanner retained PubMed bibliographic metadata for PMID 25055456 at 2026-07-30T16:30:52.649Z. PubMed recorded a metadata revision date of 2026-01-28 and an Entrez history date of 2014-07-25. PeptideScanner associated this retained record with the identity slug lixisenatide. These dates describe PubMed metadata history, not the article's original publication date.↗

  12. Literature metadata

    PubMed record PMID 25115916↗

    PeptideScanner retained PubMed bibliographic metadata for PMID 25115916 at 2026-07-30T16:30:52.653Z. PubMed recorded a metadata revision date of 2026-01-28 and an Entrez history date of 2014-08-14. PeptideScanner associated this retained record with the identity slug lixisenatide. These dates describe PubMed metadata history, not the article's original publication date.↗

  13. Literature metadata

    PubMed record PMID 25130920↗

    PeptideScanner retained PubMed bibliographic metadata for PMID 25130920 at 2026-07-30T16:30:52.654Z. PubMed recorded a metadata revision date of 2026-01-28 and an Entrez history date of 2014-08-19. PeptideScanner associated this retained record with the identity slug lixisenatide. These dates describe PubMed metadata history, not the article's original publication date.↗

  14. Literature metadata

    PubMed record PMID 26039935↗

    PeptideScanner retained PubMed bibliographic metadata for PMID 26039935 at 2026-07-30T16:30:54.214Z. PubMed recorded a metadata revision date of 2026-01-28 and an Entrez history date of 2015-06-04. PeptideScanner associated this retained record with the identity slug lixisenatide. These dates describe PubMed metadata history, not the article's original publication date.↗

  15. Literature metadata

    PubMed record PMID 26423184↗

    PeptideScanner retained PubMed bibliographic metadata for PMID 26423184 at 2026-07-30T16:30:54.263Z. PubMed recorded a metadata revision date of 2026-01-28 and an Entrez history date of 2015-10-02. PeptideScanner associated this retained record with the identity slug lixisenatide. These dates describe PubMed metadata history, not the article's original publication date.↗

  16. Literature metadata

    Insulin degludec, Lixisenatide, and Patiromer sorbitex calcium.↗

    PubMed lists PMID 27836130 in Journal of the American Pharmacists Association : JAPhA as Journal Article, with publication-date metadata of 2016 Nov-Dec (source-text precision). PeptideScanner associated the retained record with the identity slug lixisenatide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗

  17. Literature metadata

    Lixisenatide for type 2 diabetes.↗

    PubMed lists PMID 28118649 in The Medical letter on drugs and therapeutics as Journal Article, Review, with publication-date metadata of 2017-01-30 (day precision). PeptideScanner associated the retained record with the identity slug lixisenatide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗

  18. Literature metadata

    Lixisenatide (Adlyxin) for Type 2 Diabetes Mellitus.↗

    PubMed lists PMID 28925668 in American family physician as Journal Article, with publication-date metadata of 2017-08-15 (day precision). PeptideScanner associated the retained record with the identity slug lixisenatide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗

  19. Literature metadata

    Glycaemic target attainment in people with Type 2 diabetes treated with insulin glargine/lixisenatide fixed-ratio combination: a post hoc analysis of the LixiLan-O and LixiLan-L trials.↗

    PubMed lists PMID 31365765 in Diabetic medicine : a journal of the British Diabetic Association as Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2019-11-26 (day precision). PeptideScanner associated the retained record with the identity slug lixisenatide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗

  20. Literature metadata

    Lixisenatide versus insulin glulisine on top of insulin glargine in patients with type 2 diabetes mellitus: a cost-per-responder analysis in China.↗

    PubMed lists PMID 31469303 in Current medical research and opinion as Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2019-09-11 (day precision). PeptideScanner associated the retained record with the identity slug lixisenatide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗

  21. Literature metadata

    Mexican population sub-analysis of the lixilan clinical program with the fixed ratio combination of insulin glargine and lixisenatide (iGlarLixi).↗

    PubMed lists PMID 32561160 in Journal of diabetes and its complications as Clinical Trial, Phase II, Clinical Trial, Phase III, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, with publication-date metadata of 2019-05-31 (day precision). PeptideScanner associated the retained record with the identity slug lixisenatide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗

  22. Literature metadata

    Insulin glargine/lixisenatide fixed-ratio combination (iGlarLixi) compared with premix or addition of meal-time insulin to basal insulin in people with type 2 diabetes: A systematic review and Bayesi…↗

    PubMed lists PMID 32700442 in Diabetes, obesity & metabolism as Journal Article, Research Support, Non-U.S. Gov't, Systematic Review, Network Meta-Analysis, with publication-date metadata of 2020-09-03 (day precision). PeptideScanner associated the retained record with the identity slug lixisenatide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗

Source year

2025

6 records
Literature metadata · 3Regulatory · 2Clinical trials · 1
  1. Clinical trials

    ClinicalTrials.gov record NCT03439943↗

    PeptideScanner retained ClinicalTrials.gov record NCT03439943 at 2026-07-30T18:19:48.216Z. Its registry update date was 2025-11-28, and PeptideScanner's reviewed identity mapping was lixisenatide.↗

  2. Regulatory

    Lixisenatide DailyMed SPL version 23↗

    DailyMed lists Structured Product Labeling version 23 for the reviewed Lixisenatide label family with a published date of 2025-08-01. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗

  3. Regulatory

    Lixisenatide DailyMed SPL version 22↗

    DailyMed lists Structured Product Labeling version 22 for the reviewed Lixisenatide label family with a published date of 2025-06-13. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗

  4. Literature metadata

    Lixisenatide in Type 2 Diabetes and Acute Coronary Syndrome.↗

    PubMed lists PMID 26981945 in The New England journal of medicine as Letter, Comment, with publication-date metadata of 2016-03-17 (day precision). PeptideScanner associated the retained record with the identity slug lixisenatide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗

  5. Literature metadata

    Lixisenatide in Type 2 Diabetes and Acute Coronary Syndrome.↗

    PubMed lists PMID 26981946 in The New England journal of medicine as Letter, Comment, with publication-date metadata of 2016-03-17 (day precision). PeptideScanner associated the retained record with the identity slug lixisenatide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗

  6. Literature metadata

    Lixisenatide in Type 2 Diabetes and Acute Coronary Syndrome.↗

    PubMed lists PMID 26981947 in The New England journal of medicine as Letter, Comment, with publication-date metadata of 2016-03-17 (day precision). PeptideScanner associated the retained record with the identity slug lixisenatide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗

Source year

2024

4 records
Literature metadata · 2Clinical trials · 1Regulatory · 1
  1. Clinical trials

    ClinicalTrials.gov record NCT02049034↗

    PeptideScanner retained ClinicalTrials.gov record NCT02049034 at 2026-07-30T18:37:14.684Z. Its registry update date was 2024-12-16, and PeptideScanner's reviewed identity mapping was lixisenatide.↗

  2. Regulatory

    Lixisenatide DailyMed SPL version 19↗

    DailyMed lists Structured Product Labeling version 19 for the reviewed Lixisenatide label family with a published date of 2024-11-14. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗

  3. Literature metadata

    Poly(l-threonine-co-l-threonine Succinate) Thermogels for Sustained Release of Lixisenatide.↗

    PubMed lists PMID 38949062 in Biomacromolecules as Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2024-07-01 (day precision). PeptideScanner associated the retained record with the identity slug lixisenatide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗

  4. Literature metadata

    Lixisenatide.↗

    PubMed lists PMID 28179743 in Hospital pharmacy as Journal Article, with publication-date metadata of 2017-01 (month precision). PeptideScanner associated the retained record with the identity slug lixisenatide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗

Source year

2023

2 records
Literature metadata · 1Regulatory · 1
  1. Regulatory

    Lixisenatide DailyMed SPL version 18↗

    DailyMed lists Structured Product Labeling version 18 for the reviewed Lixisenatide label family with a published date of 2023-10-12. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗

  2. Literature metadata

    Comprehensive Evaluation of Combination Therapy with Basal Insulin and Either Lixisenatide or Vildagliptin in Japanese Patients with Type 2 Diabetes: A Randomized, Open-Label, Parallel-Group, Multice…↗

    PubMed lists PMID 30206903 in Diabetes therapy : research, treatment and education of diabetes and related disorders as Journal Article, with publication-date metadata of 2018-09-11 (day precision). PeptideScanner associated the retained record with the identity slug lixisenatide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗

Source year

2022

1 record
Regulatory · 1
  1. Regulatory

    Lixisenatide DailyMed SPL version 17↗

    DailyMed lists Structured Product Labeling version 17 for the reviewed Lixisenatide label family with a published date of 2022-06-20. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗

Source year

2021

2 records
Literature metadata · 1Regulatory · 1
  1. Regulatory

    Lixisenatide DailyMed SPL version 16↗

    DailyMed lists Structured Product Labeling version 16 for the reviewed Lixisenatide label family with a published date of 2021-08-09. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗

  2. Literature metadata

    Austrian Experience with Lixisenatide Under Real-Life Conditions: A Prospective Observational Study.↗

    PubMed lists PMID 30656523 in Diabetes therapy : research, treatment and education of diabetes and related disorders as Journal Article, with publication-date metadata of 2019-01-17 (day precision). PeptideScanner associated the retained record with the identity slug lixisenatide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗

Source year

2020

6 records
Regulatory · 4Clinical trials · 1Literature metadata · 1
  1. Regulatory

    Lixisenatide DailyMed SPL version 15↗

    DailyMed lists Structured Product Labeling version 15 for the reviewed Lixisenatide label family with a published date of 2020-12-04. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗

  2. Regulatory

    Lixisenatide DailyMed SPL version 14↗

    DailyMed lists Structured Product Labeling version 14 for the reviewed Lixisenatide label family with a published date of 2020-07-16. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗

  3. Clinical trials

    ClinicalTrials.gov record NCT02640118↗

    PeptideScanner retained ClinicalTrials.gov record NCT02640118 at 2026-07-30T20:27:50.520Z. Its registry update date was 2020-05-07, and PeptideScanner's reviewed identity mapping was lixisenatide.↗

  4. Regulatory

    Lixisenatide DailyMed SPL version 13↗

    DailyMed lists Structured Product Labeling version 13 for the reviewed Lixisenatide label family with a published date of 2020-03-31. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗

  5. Literature metadata

    PubMed record PMID 31873867↗

    PeptideScanner retained PubMed bibliographic metadata for PMID 31873867 at 2026-07-30T20:33:08.013Z. PubMed recorded a metadata revision date of 2020-02-26 and an Entrez history date of 2019-12-25. PeptideScanner associated this retained record with the identity slug lixisenatide. These dates describe PubMed metadata history, not the article's original publication date.↗

  6. Regulatory

    Lixisenatide DailyMed SPL version 12↗

    DailyMed lists Structured Product Labeling version 12 for the reviewed Lixisenatide label family with a published date of 2020-01-24. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗

Source year

2019

9 records
Regulatory · 5Literature metadata · 4
  1. Regulatory

    Lixisenatide DailyMed SPL version 11↗

    DailyMed lists Structured Product Labeling version 11 for the reviewed Lixisenatide label family with a published date of 2019-12-19. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗

  2. Regulatory

    Lixisenatide DailyMed SPL version 10↗

    DailyMed lists Structured Product Labeling version 10 for the reviewed Lixisenatide label family with a published date of 2019-12-12. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗

  3. Regulatory

    Lixisenatide DailyMed SPL version 9↗

    DailyMed lists Structured Product Labeling version 9 for the reviewed Lixisenatide label family with a published date of 2019-12-10. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗

  4. Regulatory

    Lixisenatide DailyMed SPL version 8↗

    DailyMed lists Structured Product Labeling version 8 for the reviewed Lixisenatide label family with a published date of 2019-11-26. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗

  5. Literature metadata

    PubMed record PMID 30736157↗

    PeptideScanner retained PubMed bibliographic metadata for PMID 30736157 at 2026-07-30T20:44:20.586Z. PubMed recorded a metadata revision date of 2019-11-20 and an Entrez history date of 2019-02-10. PeptideScanner associated this retained record with the identity slug lixisenatide. These dates describe PubMed metadata history, not the article's original publication date.↗

  6. Literature metadata

    PubMed record PMID 30736158↗

    PeptideScanner retained PubMed bibliographic metadata for PMID 30736158 at 2026-07-30T20:44:20.587Z. PubMed recorded a metadata revision date of 2019-11-20 and an Entrez history date of 2019-02-10. PeptideScanner associated this retained record with the identity slug lixisenatide. These dates describe PubMed metadata history, not the article's original publication date.↗

  7. Literature metadata

    PubMed record PMID 28420696↗

    PeptideScanner retained PubMed bibliographic metadata for PMID 28420696 at 2026-07-30T20:44:20.465Z. PubMed recorded a metadata revision date of 2019-11-20 and an Entrez history date of 2017-04-20. PeptideScanner associated this retained record with the identity slug lixisenatide. These dates describe PubMed metadata history, not the article's original publication date.↗

  8. Literature metadata

    PubMed record PMID 28428368↗

    PeptideScanner retained PubMed bibliographic metadata for PMID 28428368 at 2026-07-30T20:44:20.465Z. PubMed recorded a metadata revision date of 2019-11-20 and an Entrez history date of 2017-04-22. PeptideScanner associated this retained record with the identity slug lixisenatide. These dates describe PubMed metadata history, not the article's original publication date.↗

  9. Regulatory

    Lixisenatide DailyMed SPL version 7↗

    DailyMed lists Structured Product Labeling version 7 for the reviewed Lixisenatide label family with a published date of 2019-03-05. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗

Source year

2018

3 records
Regulatory · 3
  1. Regulatory

    Federal Register notice 2018-27805↗

    The Federal Register published notice 2018-27805, attributed to FDA and its parent HHS department, on 2018-12-26. Its official title is “Determination of Regulatory Review Period for Purposes of Patent Extension; ADLYXIN,” and PeptideScanner's exact reviewed identity mapping connects the document to Lixisenatide.↗

  2. Regulatory

    Federal Register notice 2018-07256↗

    The Federal Register published notice 2018-07256, attributed to FDA and its parent HHS department, on 2018-04-10. Its official title is “Notice of Approval of Products Under Voucher: Rare Pediatric Disease Priority Review Vouchers,” and PeptideScanner's exact reviewed identity mapping connects the document to Lixisenatide.↗

  3. Regulatory

    Lixisenatide DailyMed SPL version 6↗

    DailyMed lists Structured Product Labeling version 6 for the reviewed Lixisenatide label family with a published date of 2018-03-07. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗

Source year

2017

3 records
Regulatory · 2Clinical trials · 1
  1. Clinical trials

    ClinicalTrials.gov record NCT02745470↗

    PeptideScanner retained ClinicalTrials.gov record NCT02745470 at 2026-07-30T21:22:00.254Z. Its registry update date was 2017-11-29, and PeptideScanner's reviewed identity mapping was lixisenatide.↗

  2. Regulatory

    Lixisenatide DailyMed SPL version 5↗

    DailyMed lists Structured Product Labeling version 5 for the reviewed Lixisenatide label family with a published date of 2017-10-12. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗

  3. Regulatory

    Lixisenatide DailyMed SPL version 4↗

    DailyMed lists Structured Product Labeling version 4 for the reviewed Lixisenatide label family with a published date of 2017-09-07. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗

Source year

2016

5 records
Regulatory · 3Clinical trials · 1Literature metadata · 1
  1. Regulatory

    Lixisenatide DailyMed SPL version 1↗

    DailyMed lists Structured Product Labeling version 1 for the reviewed Lixisenatide label family with a published date of 2016-11-22. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗

  2. Regulatory

    Drugs@FDA application BLA208471↗

    The official Drugs@FDA dataset lists original submission 1 for BLA 208471 with status AP dated 2016-07-27, and names lixisenatide among the application record's active ingredients.↗

  3. Literature metadata

    PubMed record PMID 27200667↗

    PeptideScanner retained PubMed bibliographic metadata for PMID 27200667 at 2026-07-30T21:38:23.145Z. PubMed recorded a metadata revision date of 2016-05-21 and an Entrez history date of 2016-05-21. PeptideScanner associated this retained record with the identity slug lixisenatide. These dates describe PubMed metadata history, not the article's original publication date.↗

  4. Clinical trials

    ClinicalTrials.gov record NCT02276196↗

    PeptideScanner retained ClinicalTrials.gov record NCT02276196 at 2026-07-30T21:37:20.821Z. Its registry update date was 2016-04-29, and PeptideScanner's reviewed identity mapping was lixisenatide.↗

  5. Regulatory

    Federal Register notice 2016-05931↗

    The Federal Register published notice 2016-05931, attributed to FDA and its parent HHS department, on 2016-03-16. Its official title is “Endocrinologic and Metabolic Drugs Advisory Committee; Notice of Meeting,” and PeptideScanner's exact reviewed identity mapping connects the document to Lixisenatide.↗

Source year

2015

1 record
Clinical trials · 1
  1. Clinical trials

    ClinicalTrials.gov record NCT02020629↗

    PeptideScanner retained ClinicalTrials.gov record NCT02020629 at 2026-07-30T21:39:57.678Z. Its registry update date was 2015-12-15, and PeptideScanner's reviewed identity mapping was lixisenatide.↗