Profile change history

What changed for Epitalon?

A deterministic history of records added to PeptideScanner and preserved profile or record revisions connected through the reviewed Epitalon identity.

26Total events
25Record additions
1Version changes
6Cited source years

Before and after

Preserved version changes

Correction

Epitalon profile

We narrowed the status wording to what the dated FDA briefing establishes. A briefing prepared for an advisory process does not establish the current absence of a later final decision. Related substance identities remain distinct.

PeptideScanner change date
September 15, 2026
Evidence lane
Profile

Status

Before
FDA compounding safety review; final determination pending
After
FDA compounding assessment in the cited records

Evidence note

Before
FDA's Epitalon briefing describes evidence and safety questions presented to the advisory committee. Committee recommendations are nonbinding, and FDA says its final determination will follow completion of the committee process and relevant reviews.
After
FDA's July 2026 briefing evaluates epitalon free base and acetate and distinguishes the tetrapeptide from epithalamin, a pineal-gland extract. The briefing is an advisory-process assessment, not a final regulatory determination.

Related names

Before
None recorded
After
AEDG, Epithalon

Claim citations

Before
name: fda-epitalon-briefing; aliases: fda-epitalon-briefing; category: fda-epitalon-briefing, fda-pcac-peptide-meeting-2026; status: fda-epitalon-briefing, fda-pcac-peptide-meeting-2026; summary: fda-epitalon-briefing, fda-pcac-peptide-meeting-2026; evidenceNote: fda-epitalon-briefing, fda-pcac-peptide-meeting-2026
After
name: fda-epitalon-briefing; aliases: fda-epitalon-briefing; category: fda-epitalon-briefing, fda-pcac-peptide-meeting-2026; status: fda-epitalon-briefing; summary: fda-epitalon-briefing, fda-pcac-peptide-meeting-2026; evidenceNote: fda-epitalon-briefing

Collection chronology

Evidence added to PeptideScanner

Browse all 25 connected records →

Showing the latest 25 additions by PeptideScanner publication date; the complete connected record set remains available in Latest Research. Most recent addition: August 21, 2026.

Record added

Federal Register notice 2026-07361

The Federal Register published notice 2026-07361, attributed to FDA and its parent HHS department, on 2026-04-16. Its official title is “Pharmacy Compounding Advisory Committee; Notice of Meeting; Establishment of a Public Docket; Request for Comments-Bulk Drug Substances Nominated for Inclusion on the Section 503A Bulk Drug Substances List,” and PeptideScanner's exact reviewed identity mapping connects the document to BPC-157, Emideltide, Epitalon, KPV, MOTS-c, Semax and TB-500.

PeptideScanner change date
August 21, 2026
Cited source date
April 16, 2026
Evidence lane
Regulatory
Record added

PubMed record PMID 11087911

PeptideScanner retained PubMed bibliographic metadata for PMID 11087911 at 2026-07-30T20:48:24.194Z. PubMed recorded a metadata revision date of 2019-08-31 and an Entrez history date of 2000-11-23. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
August 31, 2019
Evidence lane
Literature metadata
Record added

PubMed record PMID 12049808

PeptideScanner retained PubMed bibliographic metadata for PMID 12049808 at 2026-07-30T20:50:08.377Z. PubMed recorded a metadata revision date of 2019-07-20 and an Entrez history date of 2002-06-07. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
July 20, 2019
Evidence lane
Literature metadata
Record added

PubMed record PMID 12101568

PeptideScanner retained PubMed bibliographic metadata for PMID 12101568 at 2026-07-30T21:22:56.967Z. PubMed recorded a metadata revision date of 2017-11-16 and an Entrez history date of 2002-07-10. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
November 16, 2017
Evidence lane
Literature metadata
Record added

PubMed record PMID 12209581

PeptideScanner retained PubMed bibliographic metadata for PMID 12209581 at 2026-07-30T16:30:44.156Z. PubMed recorded a metadata revision date of 2026-01-28 and an Entrez history date of 2002-09-05. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
January 28, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 12942748

PeptideScanner retained PubMed bibliographic metadata for PMID 12942748 at 2026-07-30T21:35:53.272Z. PubMed recorded a metadata revision date of 2016-10-20 and an Entrez history date of 2003-08-29. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
October 20, 2016
Evidence lane
Literature metadata
Record added

PubMed record PMID 14501183

PeptideScanner retained PubMed bibliographic metadata for PMID 14501183 at 2026-07-30T20:44:18.228Z. PubMed recorded a metadata revision date of 2019-11-08 and an Entrez history date of 2003-09-23. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
November 8, 2019
Evidence lane
Literature metadata
Record added

PubMed record PMID 15490730

PeptideScanner retained PubMed bibliographic metadata for PMID 15490730 at 2026-07-30T21:35:53.278Z. PubMed recorded a metadata revision date of 2016-10-21 and an Entrez history date of 2004-10-20. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
October 21, 2016
Evidence lane
Literature metadata
Record added

PubMed record PMID 17152723

PeptideScanner retained PubMed bibliographic metadata for PMID 17152723 at 2026-07-30T21:35:54.214Z. PubMed recorded a metadata revision date of 2016-10-21 and an Entrez history date of 2006-12-13. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
October 21, 2016
Evidence lane
Literature metadata
Record added

PubMed record PMID 17152724

PeptideScanner retained PubMed bibliographic metadata for PMID 17152724 at 2026-07-30T21:35:54.214Z. PubMed recorded a metadata revision date of 2016-10-21 and an Entrez history date of 2006-12-13. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
October 21, 2016
Evidence lane
Literature metadata
Record added

PubMed record PMID 17209456

PeptideScanner retained PubMed bibliographic metadata for PMID 17209456 at 2026-07-30T21:56:57.679Z. PubMed recorded a metadata revision date of 2013-11-21 and an Entrez history date of 2007-01-11. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
November 21, 2013
Evidence lane
Literature metadata
Record added

PubMed record PMID 17217245

PeptideScanner retained PubMed bibliographic metadata for PMID 17217245 at 2026-07-30T21:35:54.214Z. PubMed recorded a metadata revision date of 2016-10-20 and an Entrez history date of 2007-01-16. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
October 20, 2016
Evidence lane
Literature metadata
Record added

PubMed record PMID 20405731

PeptideScanner retained PubMed bibliographic metadata for PMID 20405731 at 2026-07-30T21:35:55.360Z. PubMed recorded a metadata revision date of 2016-10-21 and an Entrez history date of 2010-04-22. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
October 21, 2016
Evidence lane
Literature metadata
Record added

PubMed record PMID 25535022

PeptideScanner retained PubMed bibliographic metadata for PMID 25535022 at 2026-07-30T20:43:08.960Z. PubMed recorded a metadata revision date of 2019-12-10 and an Entrez history date of 2014-12-24. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
December 10, 2019
Evidence lane
Literature metadata
Record added

PubMed record PMID 40493162

PeptideScanner retained PubMed bibliographic metadata for PMID 40493162 at 2026-07-30T16:14:11.014Z. PubMed recorded a metadata revision date of 2026-06-13 and an Entrez history date of 2025-06-10. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 13, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 41240216

PeptideScanner retained PubMed bibliographic metadata for PMID 41240216 at 2026-07-30T16:20:41.667Z. PubMed recorded a metadata revision date of 2026-05-20 and an Entrez history date of 2025-11-15. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
May 20, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 11524632

PeptideScanner retained PubMed bibliographic metadata for PMID 11524632 at 2026-07-30T21:56:55.056Z. PubMed recorded a metadata revision date of 2013-11-21 and an Entrez history date of 2001-08-29. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 11, 2026
Cited source date
November 21, 2013
Evidence lane
Literature metadata
Record added

PubMed record PMID 12964022

PeptideScanner retained PubMed bibliographic metadata for PMID 12964022 at 2026-07-30T21:56:55.922Z. PubMed recorded a metadata revision date of 2013-11-21 and an Entrez history date of 2003-09-10. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 11, 2026
Cited source date
November 21, 2013
Evidence lane
Literature metadata
Record added

PubMed record PMID 14647006

PeptideScanner retained PubMed bibliographic metadata for PMID 14647006 at 2026-07-30T21:56:55.927Z. PubMed recorded a metadata revision date of 2013-05-20 and an Entrez history date of 2003-12-04. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 11, 2026
Cited source date
May 20, 2013
Evidence lane
Literature metadata
Record added

PubMed record PMID 15909815

PeptideScanner retained PubMed bibliographic metadata for PMID 15909815 at 2026-07-30T21:56:56.704Z. PubMed recorded a metadata revision date of 2013-11-21 and an Entrez history date of 2005-05-25. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 11, 2026
Cited source date
November 21, 2013
Evidence lane
Literature metadata
Record added

PubMed record PMID 12195242

PeptideScanner retained PubMed bibliographic metadata for PMID 12195242 at 2026-07-30T22:15:26.486Z. PubMed recorded a metadata revision date of 2012-11-15 and an Entrez history date of 2002-08-27. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 10, 2026
Cited source date
November 15, 2012
Evidence lane
Literature metadata
Record added

PubMed record PMID 12500162

PeptideScanner retained PubMed bibliographic metadata for PMID 12500162 at 2026-07-30T22:15:26.487Z. PubMed recorded a metadata revision date of 2012-11-15 and an Entrez history date of 2002-12-25. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 10, 2026
Cited source date
November 15, 2012
Evidence lane
Literature metadata
Record added

PubMed record PMID 12500171

PeptideScanner retained PubMed bibliographic metadata for PMID 12500171 at 2026-07-30T22:15:26.487Z. PubMed recorded a metadata revision date of 2012-11-15 and an Entrez history date of 2002-12-25. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 10, 2026
Cited source date
November 15, 2012
Evidence lane
Literature metadata
Record added

PubMed record PMID 16634527

PeptideScanner retained PubMed bibliographic metadata for PMID 16634527 at 2026-07-30T22:15:26.490Z. PubMed recorded a metadata revision date of 2012-11-15 and an Entrez history date of 2006-04-26. PeptideScanner associated this retained record with the identity slug epitalon. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 10, 2026
Cited source date
November 15, 2012
Evidence lane
Literature metadata
Record added

FDA committee met on seven peptide-related groups of bulk drug substances

FDA convened its Pharmacy Compounding Advisory Committee on July 23-24, 2026, to discuss free-base and acetate bulk drug substances across seven peptide-related groups.

PeptideScanner change date
July 29, 2026
Cited source date
July 24, 2026
Evidence lane
Regulatory