Profile change history

What changed for Elamipretide?

A deterministic history of records added to PeptideScanner and preserved profile or record revisions connected through the reviewed Elamipretide identity.

48Total events
47Record additions
1Version changes
8Cited source years

Before and after

Preserved version changes

Profile updated

Elamipretide profile

We rewrote the profile summary to describe the cited study record more directly. The cited source and status did not change.

PeptideScanner change date
July 27, 2026
Evidence lane
Profile

Profile summary

Before
A mitochondria-targeting peptide candidate represented in ClinicalTrials.gov.
After
A mitochondria-targeting peptide candidate. This profile cites a recruiting ClinicalTrials.gov study record.

Collection chronology

Evidence added to PeptideScanner

Browse all 47 connected records →

Showing the latest 47 additions by PeptideScanner publication date; the complete connected record set remains available in Latest Research. Most recent addition: August 21, 2026.

Record added

Federal Register notice 2024-20062

The Federal Register published notice 2024-20062, attributed to FDA and its parent HHS department, on 2024-09-06. Its official title is “Cardiovascular and Renal Drugs Advisory Committee; Notice of Meeting; Establishment of a Public Docket; Request for Comments-New Drug Application 215244 for Elamipretide Hydrochloride Injection,” and PeptideScanner's exact reviewed identity mapping connects the document to Elamipretide.

PeptideScanner change date
August 21, 2026
Cited source date
September 6, 2024
Evidence lane
Regulatory
Record added

Federal Register notice 2025-23409

The Federal Register published notice 2025-23409, attributed to FDA and its parent HHS department, on 2025-12-19. Its official title is “Issuance of Priority Review Voucher; Rare Pediatric Disease Product; FORZINITY (Elamipretide),” and PeptideScanner's exact reviewed identity mapping connects the document to Elamipretide.

PeptideScanner change date
August 21, 2026
Cited source date
December 19, 2025
Evidence lane
Regulatory
Record added

ClinicalTrials.gov record NCT06373731

PeptideScanner retained ClinicalTrials.gov record NCT06373731 at 2026-07-30T16:19:36.914Z. Its registry update date was 2026-05-20, and PeptideScanner's reviewed identity mapping was elamipretide.

PeptideScanner change date
August 14, 2026
Cited source date
May 20, 2026
Evidence lane
Clinical trials
Record added

ClinicalTrials.gov record NCT07531251

PeptideScanner retained ClinicalTrials.gov record NCT07531251 at 2026-08-10T18:10:04.223Z. Its registry update date was 2026-07-13, and PeptideScanner's reviewed identity mapping was elamipretide.

PeptideScanner change date
August 14, 2026
Cited source date
July 13, 2026
Evidence lane
Clinical trials
Record added

The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin.

PubMed lists PMID 23813215 in Journal of the American Society of Nephrology : JASN as Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, with publication-date metadata of 2013-07-11 (day precision). PeptideScanner associated the retained record with the identity slug elamipretide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
October 21, 2021
Evidence lane
Literature metadata
Record added

Abnormalities of Mitochondrial Dynamics in the Failing Heart: Normalization Following Long-Term Therapy with Elamipretide.

PubMed lists PMID 29951944 in Cardiovascular drugs and therapy as Journal Article, with publication-date metadata of 2018-08 (month precision). PeptideScanner associated the retained record with the identity slug elamipretide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
March 12, 2024
Evidence lane
Literature metadata
Record added

A randomized crossover trial of elamipretide in adults with primary mitochondrial myopathy.

PubMed lists PMID 32096613 in Journal of cachexia, sarcopenia and muscle as Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, with publication-date metadata of 2020-02-25 (day precision). PeptideScanner associated the retained record with the identity slug elamipretide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
August 1, 2024
Evidence lane
Literature metadata
Record added

Mitochondrial protein interaction landscape of SS-31.

PubMed lists PMID 32554501 in Proceedings of the National Academy of Sciences of the United States of America as Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, with publication-date metadata of 2020-06-17 (day precision). PeptideScanner associated the retained record with the identity slug elamipretide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
March 30, 2024
Evidence lane
Literature metadata
Record added

Elamipretide for Barth syndrome cardiomyopathy: gradual rebuilding of a failed power grid.

PubMed lists PMID 34623544 in Heart failure reviews as Journal Article, Review, Research Support, Non-U.S. Gov't, with publication-date metadata of 2021-10-08 (day precision). PeptideScanner associated the retained record with the identity slug elamipretide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
July 28, 2025
Evidence lane
Literature metadata
Record added

Targeting mitochondrial dysfunction with elamipretide.

PubMed lists PMID 35037146 in Heart failure reviews as Journal Article, Review, Research Support, Non-U.S. Gov't, with publication-date metadata of 2022-01-17 (day precision). PeptideScanner associated the retained record with the identity slug elamipretide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
July 28, 2025
Evidence lane
Literature metadata
Record added

Use of Elamipretide in patients assigned treatment in the compassionate use program: Case series in pediatric patients with rare orphan diseases.

PubMed lists PMID 36636586 in JIMD reports as Journal Article, with publication-date metadata of 2022-09-21 (day precision). PeptideScanner associated the retained record with the identity slug elamipretide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
August 15, 2023
Evidence lane
Literature metadata
Record added

Intermittent treatment with elamipretide preserves exercise tolerance in aged female mice.

PubMed lists PMID 36840897 in GeroScience as Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, with publication-date metadata of 2023-02-25 (day precision). PeptideScanner associated the retained record with the identity slug elamipretide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
July 19, 2024
Evidence lane
Literature metadata
Record added

Identifying responders to elamipretide in Barth syndrome: Hierarchical clustering for time series data.

PubMed lists PMID 37041653 in Orphanet journal of rare diseases as Randomized Controlled Trial, Journal Article, Research Support, Non-U.S. Gov't, with publication-date metadata of 2023-04-11 (day precision). PeptideScanner associated the retained record with the identity slug elamipretide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
January 27, 2026
Evidence lane
Literature metadata
Record added

Temporal evolution of the heart failure phenotype in Barth syndrome and treatment with elamipretide.

PubMed lists PMID 37325898 in Future cardiology as Journal Article, Review, Research Support, Non-U.S. Gov't, with publication-date metadata of 2023-06-16 (day precision). PeptideScanner associated the retained record with the identity slug elamipretide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
January 27, 2026
Evidence lane
Literature metadata
Record added

Expanded-access use of elamipretide in a critically ill patient with Barth syndrome.

PubMed lists PMID 39669625 in Genetics in medicine open as Journal Article, with publication-date metadata of 2024-06-22 (day precision). PeptideScanner associated the retained record with the identity slug elamipretide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
December 14, 2024
Evidence lane
Literature metadata
Record added

Expanded-access use of elamipretide in a newborn with Barth syndrome: a case report.

PubMed lists PMID 39917770 in European heart journal. Case reports as Case Reports, Journal Article, with publication-date metadata of 2025-01-22 (day precision). PeptideScanner associated the retained record with the identity slug elamipretide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
February 8, 2025
Evidence lane
Literature metadata
Record added

Elamipretide in the Management of Barth Syndrome: Current Evidence and a Case Report.

PubMed lists PMID 40816230 in Molecular genetics and metabolism as Journal Article, Case Reports, Review, with publication-date metadata of 2025-08-11 (day precision). PeptideScanner associated the retained record with the identity slug elamipretide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
November 18, 2025
Evidence lane
Literature metadata
Record added

Elamipretide: The first cardiolipin-directed mitochondrial therapeutic for Barth syndrome approved under accelerated approval.

PubMed lists PMID 41260682 in Drug discoveries & therapeutics as Letter, with publication-date metadata of 2025-11-20 (day precision). PeptideScanner associated the retained record with the identity slug elamipretide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

PeptideScanner change date
August 13, 2026
Cited source date
January 14, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 37268435

PeptideScanner retained PubMed bibliographic metadata for PMID 37268435 at 2026-07-30T16:20:36.524Z. PubMed recorded a metadata revision date of 2026-05-18 and an Entrez history date of 2023-06-02. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
May 18, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 38237649

PeptideScanner retained PubMed bibliographic metadata for PMID 38237649 at 2026-08-10T18:13:32.340Z. PubMed recorded a metadata revision date of 2026-07-09 and an Entrez history date of 2024-01-18. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
July 9, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 38602181

PeptideScanner retained PubMed bibliographic metadata for PMID 38602181 at 2026-07-30T16:11:44.832Z. PubMed recorded a metadata revision date of 2026-07-01 and an Entrez history date of 2024-04-11. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
July 1, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 38688894

PeptideScanner retained PubMed bibliographic metadata for PMID 38688894 at 2026-07-30T16:14:06.935Z. PubMed recorded a metadata revision date of 2026-06-27 and an Entrez history date of 2024-04-30. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 27, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 38990651

PeptideScanner retained PubMed bibliographic metadata for PMID 38990651 at 2026-07-30T16:14:08.785Z. PubMed recorded a metadata revision date of 2026-06-01 and an Entrez history date of 2024-07-11. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 1, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 39574155

PeptideScanner retained PubMed bibliographic metadata for PMID 39574155 at 2026-07-30T16:20:39.074Z. PubMed recorded a metadata revision date of 2026-05-19 and an Entrez history date of 2024-11-22. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
May 19, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 39605874

PeptideScanner retained PubMed bibliographic metadata for PMID 39605874 at 2026-07-30T16:20:39.082Z. PubMed recorded a metadata revision date of 2026-05-18 and an Entrez history date of 2024-11-28. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
May 18, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 40570323

PeptideScanner retained PubMed bibliographic metadata for PMID 40570323 at 2026-07-30T16:14:11.030Z. PubMed recorded a metadata revision date of 2026-06-17 and an Entrez history date of 2025-06-26. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 17, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 41500837

PeptideScanner retained PubMed bibliographic metadata for PMID 41500837 at 2026-07-30T16:14:13.067Z. PubMed recorded a metadata revision date of 2026-06-25 and an Entrez history date of 2026-01-07. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 25, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 41596703

PeptideScanner retained PubMed bibliographic metadata for PMID 41596703 at 2026-07-30T16:11:44.884Z. PubMed recorded a metadata revision date of 2026-07-01 and an Entrez history date of 2026-01-28. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
July 1, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 41612464

PeptideScanner retained PubMed bibliographic metadata for PMID 41612464 at 2026-07-30T16:14:14.832Z. PubMed recorded a metadata revision date of 2026-06-27 and an Entrez history date of 2026-01-30. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 27, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 41801306

PeptideScanner retained PubMed bibliographic metadata for PMID 41801306 at 2026-08-10T18:13:44.801Z. PubMed recorded a metadata revision date of 2026-07-10 and an Entrez history date of 2026-03-09. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
July 10, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42082001

PeptideScanner retained PubMed bibliographic metadata for PMID 42082001 at 2026-07-30T16:14:16.712Z. PubMed recorded a metadata revision date of 2026-06-12 and an Entrez history date of 2026-05-04. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 12, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42290373

PeptideScanner retained PubMed bibliographic metadata for PMID 42290373 at 2026-07-30T16:14:18.165Z. PubMed recorded a metadata revision date of 2026-06-15 and an Entrez history date of 2026-06-15. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 15, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42291734

PeptideScanner retained PubMed bibliographic metadata for PMID 42291734 at 2026-07-30T16:14:19.224Z. PubMed recorded a metadata revision date of 2026-06-15 and an Entrez history date of 2026-06-15. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
June 15, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42415111

PeptideScanner retained PubMed bibliographic metadata for PMID 42415111 at 2026-08-10T18:13:53.859Z. PubMed recorded a metadata revision date of 2026-07-07 and an Entrez history date of 2026-07-07. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 12, 2026
Cited source date
July 7, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 35611788

PeptideScanner retained PubMed bibliographic metadata for PMID 35611788 at 2026-08-10T18:13:32.311Z. PubMed recorded a metadata revision date of 2026-07-26 and an Entrez history date of 2022-05-25. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 11, 2026
Cited source date
July 26, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42219795

PeptideScanner retained PubMed bibliographic metadata for PMID 42219795 at 2026-08-10T18:13:50.715Z. PubMed recorded a metadata revision date of 2026-07-17 and an Entrez history date of 2026-06-01. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 11, 2026
Cited source date
July 17, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42443448

PeptideScanner retained PubMed bibliographic metadata for PMID 42443448 at 2026-08-10T18:13:55.249Z. PubMed recorded a metadata revision date of 2026-07-13 and an Entrez history date of 2026-07-13. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 11, 2026
Cited source date
July 13, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42448476

PeptideScanner retained PubMed bibliographic metadata for PMID 42448476 at 2026-08-10T18:13:55.255Z. PubMed recorded a metadata revision date of 2026-07-14 and an Entrez history date of 2026-07-14. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 11, 2026
Cited source date
July 14, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 17151329

PeptideScanner retained PubMed bibliographic metadata for PMID 17151329 at 2026-07-30T21:55:37.962Z. PubMed recorded a metadata revision date of 2014-11-20 and an Entrez history date of 2006-12-08. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 10, 2026
Cited source date
November 20, 2014
Evidence lane
Literature metadata
Record added

PubMed record PMID 21697135

PeptideScanner retained PubMed bibliographic metadata for PMID 21697135 at 2026-07-30T21:57:00.496Z. PubMed recorded a metadata revision date of 2013-11-21 and an Entrez history date of 2011-06-24. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 10, 2026
Cited source date
November 21, 2013
Evidence lane
Literature metadata
Record added

PubMed record PMID 42450582

PeptideScanner retained PubMed bibliographic metadata for PMID 42450582 at 2026-08-10T18:13:55.269Z. PubMed recorded a metadata revision date of 2026-07-26 and an Entrez history date of 2026-07-15. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 10, 2026
Cited source date
July 26, 2026
Evidence lane
Literature metadata
Record added

PubMed record PMID 42456009

PeptideScanner retained PubMed bibliographic metadata for PMID 42456009 at 2026-08-10T18:13:55.284Z. PubMed recorded a metadata revision date of 2026-07-27 and an Entrez history date of 2026-07-15. PeptideScanner associated this retained record with the identity slug elamipretide. These dates describe PubMed metadata history, not the article's original publication date.

PeptideScanner change date
August 10, 2026
Cited source date
July 27, 2026
Evidence lane
Literature metadata
Record added

ClinicalTrials.gov record NCT02788747

PeptideScanner retained ClinicalTrials.gov record NCT02788747 at 2026-07-30T20:27:50.521Z. Its registry update date was 2020-05-14, and PeptideScanner's reviewed identity mapping was elamipretide.

PeptideScanner change date
August 9, 2026
Cited source date
May 14, 2020
Evidence lane
Clinical trials
Record added

ClinicalTrials.gov record NCT03098797

PeptideScanner retained ClinicalTrials.gov record NCT03098797 at 2026-07-30T18:46:20.414Z. Its registry update date was 2024-04-16, and PeptideScanner's reviewed identity mapping was elamipretide.

PeptideScanner change date
August 9, 2026
Cited source date
April 16, 2024
Evidence lane
Clinical trials
Record added

ClinicalTrials.gov record NCT05162768

PeptideScanner retained ClinicalTrials.gov record NCT05162768 at 2026-07-30T18:20:54.428Z. Its registry update date was 2025-10-24, and PeptideScanner's reviewed identity mapping was elamipretide.

PeptideScanner change date
August 8, 2026
Cited source date
October 24, 2025
Evidence lane
Clinical trials
Record added

ClinicalTrials.gov record NCT05168774

PeptideScanner retained ClinicalTrials.gov record NCT05168774 at 2026-07-30T18:18:33.506Z. Its registry update date was 2025-12-12, and PeptideScanner's reviewed identity mapping was elamipretide.

PeptideScanner change date
August 8, 2026
Cited source date
December 12, 2025
Evidence lane
Clinical trials