Cross-source evidence timeline
Afamelanotide research timeline
Follow 55 selected, directly cited source records from September 15, 2009 through July 27, 2026. This timeline joins source lanes for navigation; it does not infer that one record confirms another.
Source year
2026
Clinical trials
ClinicalTrials.gov record NCT06388642↗
PeptideScanner retained ClinicalTrials.gov record NCT06388642 at 2026-08-10T18:10:03.859Z. Its registry update date was 2026-07-27, and PeptideScanner's reviewed identity mapping was afamelanotide.↗
Added to PeptideScanner August 13, 2026Literature metadata
PubMed record PMID 41547183↗
PeptideScanner retained PubMed bibliographic metadata for PMID 41547183 at 2026-07-30T16:14:14.777Z. PubMed recorded a metadata revision date of 2026-06-26 and an Entrez history date of 2026-01-17. PeptideScanner associated this retained record with the identity slug afamelanotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 10, 2026Regulatory
Afamelanotide DailyMed SPL version 11↗
DailyMed lists Structured Product Labeling version 11 for the reviewed Afamelanotide label family with a published date of 2026-05-13. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Literature metadata
PubMed record PMID 41793078↗
PeptideScanner retained PubMed bibliographic metadata for PMID 41793078 at 2026-07-30T16:23:41.287Z. PubMed recorded a metadata revision date of 2026-03-07 and an Entrez history date of 2026-03-07. PeptideScanner associated this retained record with the identity slug afamelanotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Literature metadata
PubMed record PMID 38634774↗
PeptideScanner retained PubMed bibliographic metadata for PMID 38634774 at 2026-07-30T16:23:36.263Z. PubMed recorded a metadata revision date of 2026-03-06 and an Entrez history date of 2024-04-18. PeptideScanner associated this retained record with the identity slug afamelanotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Literature metadata
PubMed record PMID 38736212↗
PeptideScanner retained PubMed bibliographic metadata for PMID 38736212 at 2026-07-30T16:23:36.274Z. PubMed recorded a metadata revision date of 2026-03-06 and an Entrez history date of 2024-05-13. PeptideScanner associated this retained record with the identity slug afamelanotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Regulatory
Afamelanotide DailyMed SPL version 10↗
DailyMed lists Structured Product Labeling version 10 for the reviewed Afamelanotide label family with a published date of 2026-02-06. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Literature metadata
PubMed record PMID 25494545↗
PeptideScanner retained PubMed bibliographic metadata for PMID 25494545 at 2026-07-30T16:30:52.686Z. PubMed recorded a metadata revision date of 2026-01-28 and an Entrez history date of 2014-12-16. PeptideScanner associated this retained record with the identity slug afamelanotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Literature metadata
From darkness to light: Case report on afamelanotide-treatment in a 9-year-old child with erythropoietic protoporphyria.↗
PubMed lists PMID 41542313 in JAAD case reports as Case Reports, Journal Article, with publication-date metadata of 2025-11-24 (day precision). PeptideScanner associated the retained record with the identity slug afamelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: November 24, 2025 · day precisionAdded to PeptideScanner August 13, 2026
Source year
2025
Regulatory
Afamelanotide DailyMed SPL version 9↗
DailyMed lists Structured Product Labeling version 9 for the reviewed Afamelanotide label family with a published date of 2025-11-17. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Literature metadata
Afamelanotide in managing cutaneous phototoxicity in erythropoietic protoporphyria: a Scottish perspective.↗
PubMed lists PMID 40692281 in Clinical and experimental dermatology as Journal Article, with publication-date metadata of 2025-10-27 (day precision). PeptideScanner associated the retained record with the identity slug afamelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: October 27, 2025 · day precisionAdded to PeptideScanner August 13, 2026
Source year
2024
Regulatory
Afamelanotide DailyMed SPL version 8↗
DailyMed lists Structured Product Labeling version 8 for the reviewed Afamelanotide label family with a published date of 2024-08-16. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Literature metadata
Afamelanotide in protoporphyria and other skin diseases: a review.↗
PubMed lists PMID 38784937 in Postepy dermatologii i alergologii as Journal Article, Review, with publication-date metadata of 2024-04-12 (day precision). PeptideScanner associated the retained record with the identity slug afamelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: April 12, 2024 · day precisionAdded to PeptideScanner August 13, 2026
Source year
2023
Literature metadata
Advances in the management of erythropoietic protoporphyria - role of afamelanotide.↗
PubMed lists PMID 28003770 in The application of clinical genetics as Review, Journal Article, with publication-date metadata of 2016-12-12 (day precision). PeptideScanner associated the retained record with the identity slug afamelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: December 12, 2016 · day precisionAdded to PeptideScanner August 13, 2026Regulatory
Afamelanotide DailyMed SPL version 7↗
DailyMed lists Structured Product Labeling version 7 for the reviewed Afamelanotide label family with a published date of 2023-10-17. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Clinical trials
ClinicalTrials.gov record NCT04525157↗
PeptideScanner retained ClinicalTrials.gov record NCT04525157 at 2026-07-30T19:08:50.172Z. Its registry update date was 2023-09-22, and PeptideScanner's reviewed identity mapping was afamelanotide.↗
Added to PeptideScanner August 8, 2026Regulatory
Afamelanotide DailyMed SPL version 6↗
DailyMed lists Structured Product Labeling version 6 for the reviewed Afamelanotide label family with a published date of 2023-05-17. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Clinical trials
ClinicalTrials.gov record NCT04962503↗
PeptideScanner retained ClinicalTrials.gov record NCT04962503 at 2026-07-30T19:14:02.188Z. Its registry update date was 2023-04-11, and PeptideScanner's reviewed identity mapping was afamelanotide.↗
Added to PeptideScanner August 8, 2026Regulatory
Federal Register notice 2023-03364↗
The Federal Register published notice 2023-03364, attributed to FDA and its parent HHS department, on 2023-02-17. Its official title is “Product-Specific Guidances; Draft and Revised Draft Guidances for Industry; Availability,” and PeptideScanner's exact reviewed identity mapping connects the document to Afamelanotide, Glucagon, Leuprolide and Vosoritide.↗
Added to PeptideScanner August 21, 2026Clinical trials
ClinicalTrials.gov record NCT05368857↗
PeptideScanner retained ClinicalTrials.gov record NCT05368857 at 2026-07-30T19:16:22.169Z. Its registry update date was 2023-02-09, and PeptideScanner's reviewed identity mapping was afamelanotide.↗
Added to PeptideScanner August 9, 2026Regulatory
Afamelanotide DailyMed SPL version 5↗
DailyMed lists Structured Product Labeling version 5 for the reviewed Afamelanotide label family with a published date of 2023-01-24. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026
Source year
2022
Literature metadata
Afamelanotide implants and narrow-band ultraviolet B phototherapy for the treatment of nonsegmental vitiligo in Asians.↗
PubMed lists PMID 31987791 in Journal of the American Academy of Dermatology as Letter, Randomized Controlled Trial, with publication-date metadata of 2020-01-25 (day precision). PeptideScanner associated the retained record with the identity slug afamelanotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.↗
Attributed publication date: January 25, 2020 · day precisionAdded to PeptideScanner August 13, 2026
Source year
2021
Regulatory
Federal Register notice 2021-24074↗
The Federal Register published notice 2021-24074, attributed to FDA and its parent HHS department, on 2021-11-04. Its official title is “Determination of Regulatory Review Period for Purposes of Patent Extension; SCENESSE,” and PeptideScanner's exact reviewed identity mapping connects the document to Afamelanotide.↗
Added to PeptideScanner August 21, 2026Clinical trials
ClinicalTrials.gov record NCT04943159↗
PeptideScanner retained ClinicalTrials.gov record NCT04943159 at 2026-07-30T19:57:27.404Z. Its registry update date was 2021-10-26, and PeptideScanner's reviewed identity mapping was afamelanotide.↗
Added to PeptideScanner August 9, 2026Clinical trials
ClinicalTrials.gov record NCT00979745↗
PeptideScanner retained ClinicalTrials.gov record NCT00979745 at 2026-07-30T19:57:27.405Z. Its registry update date was 2021-10-12, and PeptideScanner's reviewed identity mapping was afamelanotide.↗
Added to PeptideScanner August 9, 2026Regulatory
Afamelanotide DailyMed SPL version 4↗
DailyMed lists Structured Product Labeling version 4 for the reviewed Afamelanotide label family with a published date of 2021-10-04. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Clinical trials
ClinicalTrials.gov record NCT04425746↗
PeptideScanner retained ClinicalTrials.gov record NCT04425746 at 2026-07-30T19:57:27.405Z. Its registry update date was 2021-10-01, and PeptideScanner's reviewed identity mapping was afamelanotide.↗
Added to PeptideScanner August 9, 2026Clinical trials
ClinicalTrials.gov record NCT04704713↗
PeptideScanner retained ClinicalTrials.gov record NCT04704713 at 2026-07-30T20:05:17.854Z. Its registry update date was 2021-03-19, and PeptideScanner's reviewed identity mapping was afamelanotide.↗
Added to PeptideScanner August 9, 2026
Source year
2020
Clinical trials
ClinicalTrials.gov record NCT04578496↗
PeptideScanner retained ClinicalTrials.gov record NCT04578496 at 2026-07-30T20:20:00.372Z. Its registry update date was 2020-11-19, and PeptideScanner's reviewed identity mapping was afamelanotide.↗
Added to PeptideScanner August 9, 2026Literature metadata
PubMed record PMID 32459219↗
PeptideScanner retained PubMed bibliographic metadata for PMID 32459219 at 2026-07-30T20:28:46.334Z. PubMed recorded a metadata revision date of 2020-05-29 and an Entrez history date of 2020-05-28. PeptideScanner associated this retained record with the identity slug afamelanotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Regulatory
Afamelanotide DailyMed SPL version 3↗
DailyMed lists Structured Product Labeling version 3 for the reviewed Afamelanotide label family with a published date of 2020-04-15. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Regulatory
Afamelanotide DailyMed SPL version 2↗
DailyMed lists Structured Product Labeling version 2 for the reviewed Afamelanotide label family with a published date of 2020-03-27. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Literature metadata
PubMed record PMID 28063031↗
PeptideScanner retained PubMed bibliographic metadata for PMID 28063031 at 2026-07-30T20:31:47.806Z. PubMed recorded a metadata revision date of 2020-03-06 and an Entrez history date of 2017-01-08. PeptideScanner associated this retained record with the identity slug afamelanotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026
Source year
2019
Regulatory
Afamelanotide DailyMed SPL version 1↗
DailyMed lists Structured Product Labeling version 1 for the reviewed Afamelanotide label family with a published date of 2019-12-31. PeptideScanner retained the exact versioned ZIP byte count and SHA-256 receipt without republishing its contents.↗
Added to PeptideScanner August 22, 2026Literature metadata
PubMed record PMID 30517779↗
PeptideScanner retained PubMed bibliographic metadata for PMID 30517779 at 2026-07-30T20:44:20.583Z. PubMed recorded a metadata revision date of 2019-11-20 and an Entrez history date of 2018-12-06. PeptideScanner associated this retained record with the identity slug afamelanotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Clinical trials
ClinicalTrials.gov record NCT01097044↗
PeptideScanner retained ClinicalTrials.gov record NCT01097044 at 2026-07-30T20:44:36.694Z. Its registry update date was 2019-10-28, and PeptideScanner's reviewed identity mapping was afamelanotide.↗
Added to PeptideScanner August 9, 2026Clinical trials
ClinicalTrials.gov record NCT04053270↗
PeptideScanner retained ClinicalTrials.gov record NCT04053270 at 2026-07-30T20:44:36.678Z. Its registry update date was 2019-10-10, and PeptideScanner's reviewed identity mapping was afamelanotide.↗
Added to PeptideScanner August 9, 2026Regulatory
Drugs@FDA application NDA210797↗
The official Drugs@FDA dataset lists original submission 1 for NDA 210797 with status AP dated 2019-10-08, and names afamelanotide among the application record's active ingredients.↗
Added to PeptideScanner August 14, 2026Clinical trials
ClinicalTrials.gov record NCT01605136↗
PeptideScanner retained ClinicalTrials.gov record NCT01605136 at 2026-07-30T20:45:58.280Z. Its registry update date was 2019-09-19, and PeptideScanner's reviewed identity mapping was afamelanotide.↗
Added to PeptideScanner August 9, 2026
Source year
2018
Literature metadata
PubMed record PMID 25607635↗
PeptideScanner retained PubMed bibliographic metadata for PMID 25607635 at 2026-07-30T21:09:14.737Z. PubMed recorded a metadata revision date of 2018-12-02 and an Entrez history date of 2015-01-22. PeptideScanner associated this retained record with the identity slug afamelanotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Literature metadata
PubMed record PMID 25607828↗
PeptideScanner retained PubMed bibliographic metadata for PMID 25607828 at 2026-07-30T21:09:14.737Z. PubMed recorded a metadata revision date of 2018-12-02 and an Entrez history date of 2015-01-22. PeptideScanner associated this retained record with the identity slug afamelanotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Literature metadata
PubMed record PMID 26132941↗
PeptideScanner retained PubMed bibliographic metadata for PMID 26132941 at 2026-07-30T21:09:16.183Z. PubMed recorded a metadata revision date of 2018-11-13 and an Entrez history date of 2015-07-02. PeptideScanner associated this retained record with the identity slug afamelanotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Clinical trials
ClinicalTrials.gov record NCT03634137↗
PeptideScanner retained ClinicalTrials.gov record NCT03634137 at 2026-07-30T21:10:03.005Z. Its registry update date was 2018-08-16, and PeptideScanner's reviewed identity mapping was afamelanotide.↗
Added to PeptideScanner August 14, 2026
Source year
2017
Literature metadata
PubMed record PMID 25402764↗
PeptideScanner retained PubMed bibliographic metadata for PMID 25402764 at 2026-07-30T21:22:57.992Z. PubMed recorded a metadata revision date of 2017-11-16 and an Entrez history date of 2014-11-18. PeptideScanner associated this retained record with the identity slug afamelanotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Literature metadata
PubMed record PMID 26979527↗
PeptideScanner retained PubMed bibliographic metadata for PMID 26979527 at 2026-07-30T21:22:57.999Z. PubMed recorded a metadata revision date of 2017-11-16 and an Entrez history date of 2016-03-17. PeptideScanner associated this retained record with the identity slug afamelanotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 12, 2026Literature metadata
PubMed record PMID 23407924↗
PeptideScanner retained PubMed bibliographic metadata for PMID 23407924 at 2026-07-30T21:22:57.984Z. PubMed recorded a metadata revision date of 2017-11-16 and an Entrez history date of 2013-02-15. PeptideScanner associated this retained record with the identity slug afamelanotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 11, 2026Literature metadata
PubMed record PMID 23884489↗
PeptideScanner retained PubMed bibliographic metadata for PMID 23884489 at 2026-07-30T21:22:57.985Z. PubMed recorded a metadata revision date of 2017-11-16 and an Entrez history date of 2013-07-26. PeptideScanner associated this retained record with the identity slug afamelanotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 11, 2026Literature metadata
PubMed record PMID 25230094↗
PeptideScanner retained PubMed bibliographic metadata for PMID 25230094 at 2026-07-30T21:22:57.990Z. PubMed recorded a metadata revision date of 2017-11-16 and an Entrez history date of 2014-09-18. PeptideScanner associated this retained record with the identity slug afamelanotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 11, 2026Literature metadata
PubMed record PMID 25470471↗
PeptideScanner retained PubMed bibliographic metadata for PMID 25470471 at 2026-07-30T21:22:57.992Z. PubMed recorded a metadata revision date of 2017-11-16 and an Entrez history date of 2014-12-04. PeptideScanner associated this retained record with the identity slug afamelanotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 11, 2026Literature metadata
PubMed record PMID 21073357↗
PeptideScanner retained PubMed bibliographic metadata for PMID 21073357 at 2026-07-30T21:22:57.974Z. PubMed recorded a metadata revision date of 2017-11-16 and an Entrez history date of 2010-11-16. PeptideScanner associated this retained record with the identity slug afamelanotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 10, 2026Literature metadata
PubMed record PMID 21597671↗
PeptideScanner retained PubMed bibliographic metadata for PMID 21597671 at 2026-07-30T21:22:57.976Z. PubMed recorded a metadata revision date of 2017-11-16 and an Entrez history date of 2011-05-21. PeptideScanner associated this retained record with the identity slug afamelanotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 10, 2026Literature metadata
PubMed record PMID 23277150↗
PeptideScanner retained PubMed bibliographic metadata for PMID 23277150 at 2026-07-30T21:22:57.983Z. PubMed recorded a metadata revision date of 2017-11-16 and an Entrez history date of 2013-01-02. PeptideScanner associated this retained record with the identity slug afamelanotide. These dates describe PubMed metadata history, not the article's original publication date.↗
Added to PeptideScanner August 10, 2026
Source year
2013
Clinical trials
ClinicalTrials.gov record NCT01382589↗
PeptideScanner retained ClinicalTrials.gov record NCT01382589 at 2026-07-30T21:55:56.622Z. Its registry update date was 2013-03-22, and PeptideScanner's reviewed identity mapping was afamelanotide.↗
Added to PeptideScanner August 9, 2026Clinical trials
ClinicalTrials.gov record NCT01430195↗
PeptideScanner retained ClinicalTrials.gov record NCT01430195 at 2026-07-30T21:55:56.618Z. Its registry update date was 2013-03-22, and PeptideScanner's reviewed identity mapping was afamelanotide.↗
Added to PeptideScanner August 9, 2026
Source year
2009
Clinical trials
ClinicalTrials.gov record NCT00859534↗
PeptideScanner retained ClinicalTrials.gov record NCT00859534 at 2026-07-30T22:26:45.018Z. Its registry update date was 2009-09-15, and PeptideScanner's reviewed identity mapping was afamelanotide.↗
Added to PeptideScanner August 9, 2026