# Discovery of Biased Dual-Agonists of Glucagon-Like Peptide 1 and Glucagon Receptors through Mutation of a Conserved Aspartate.

> PubMed lists PMID 42445014 in ACS medicinal chemistry letters as Journal Article, with publication-date metadata of 2026-06-11 (day precision). PeptideScanner associated the retained record with the identity slug glucagon. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

- Evidence object: `story:pubmed-pmid-42445014-glucagon:v1`
- Evidence domain: Literature metadata
- Date in source: 2026-07-14
- Source checked: 2026-08-10
- Published by PeptideScanner: 2026-08-13
- Story landing page: https://peptidescanner.com/stories/pubmed-pmid-42445014-glucagon/
- JSON record: https://peptidescanner.com/evidence/v1/objects/pubmed-pmid-42445014-glucagon-v1.json
- Content SHA-256: `756c8801ea19b9ba667180b693e8ee4012fdb7da086230bfab74ffe2e6693f8b`

## Claims and source pins

### Headline

Discovery of Biased Dual-Agonists of Glucagon-Like Peptide 1 and Glucagon Receptors through Mutation of a Conserved Aspartate. ([`pubmed-observation-pmid-42445014-2026-07-14-e1fa28e929e9`](#source-pubmed-observation-pmid-42445014-2026-07-14-e1fa28e929e9))

### Summary

PubMed lists PMID 42445014 in ACS medicinal chemistry letters as Journal Article, with publication-date metadata of 2026-06-11 (day precision). PeptideScanner associated the retained record with the identity slug glucagon. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings. ([`pubmed-observation-pmid-42445014-2026-07-14-e1fa28e929e9`](#source-pubmed-observation-pmid-42445014-2026-07-14-e1fa28e929e9))

### Paragraph 1

PubMed lists PMID 42445014 in ACS medicinal chemistry letters as Journal Article, with publication-date metadata of 2026-06-11 (day precision). PeptideScanner associated the retained record with the identity slug glucagon. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings. ([`pubmed-observation-pmid-42445014-2026-07-14-e1fa28e929e9`](#source-pubmed-observation-pmid-42445014-2026-07-14-e1fa28e929e9))

### Paragraph 2

This page reproduces bounded bibliographic metadata attributed to PubMed. Its title and publication details are source metadata, not PeptideScanner's endorsement or an assertion of safety, efficacy, or scientific truth. ([`pubmed-observation-pmid-42445014-2026-07-14-e1fa28e929e9`](#source-pubmed-observation-pmid-42445014-2026-07-14-e1fa28e929e9))

## Sources

<a id="source-pubmed-observation-pmid-42445014-2026-07-14-e1fa28e929e9"></a>
- **Discovery of Biased Dual-Agonists of Glucagon-Like Peptide 1 and Glucagon Receptors through Mutation of a Conserved Aspartate. · retained source version 1:2026-07-14:current:e1fa28e929e9fed3b2a5a655bec19cb27bf1e9ad9d5a84fbfd551aa58815a7ef** — PubMed; class A. [Open source](https://pubmed.ncbi.nlm.nih.gov/42445014/) (`pubmed-observation-pmid-42445014-2026-07-14-e1fa28e929e9`)

## Correction lineage

No correction is recorded for this version.

## Reporting boundaries and unknowns

PeptideScanner reproduces bounded bibliographic metadata attributed to PubMed. It does not summarize or endorse the article's findings.

- Sources outside the selected public PeptideScanner bundle may exist and are not represented by this object.
- This object does not determine whether cited records agree, corroborate one another, or establish scientific truth.
- This object does not determine safety, efficacy, causality, or suitability for any person.

Methodology: https://peptidescanner.com/methodology/
Medical disclaimer: https://peptidescanner.com/medical-disclaimer/

## Suggested citation

PeptideScanner. "Discovery of Biased Dual-Agonists of Glucagon-Like Peptide 1 and Glucagon Receptors through Mutation of a Conserved Aspartate." Version 1, published 2026-08-13. https://peptidescanner.com/evidence/v1/objects/pubmed-pmid-42445014-glucagon-v1.json SHA-256: 756c8801ea19b9ba667180b693e8ee4012fdb7da086230bfab74ffe2e6693f8b.