# Clarification of trial end points presented in a recent review of linaclotide.

> PubMed lists PMID 22149576 in Expert review of gastroenterology & hepatology as Letter, Comment, with publication-date metadata of 2012-02 (month precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings.

- Evidence object: `story:pubmed-pmid-22149576-linaclotide:v1`
- Evidence domain: Literature metadata
- Date in source: 2018-12-01
- Source checked: 2026-07-30
- Published by PeptideScanner: 2026-08-13
- Story landing page: https://peptidescanner.com/stories/pubmed-pmid-22149576-linaclotide/
- JSON record: https://peptidescanner.com/evidence/v1/objects/pubmed-pmid-22149576-linaclotide-v1.json
- Content SHA-256: `f36ffb473318e8c33fd18a6d5e9a07e199ead4a6fac1ff5c85c4e262c16f3d1a`

## Claims and source pins

### Headline

Clarification of trial end points presented in a recent review of linaclotide. ([`pubmed-observation-pmid-22149576-2018-12-01-b2b7d1063c8d`](#source-pubmed-observation-pmid-22149576-2018-12-01-b2b7d1063c8d))

### Summary

PubMed lists PMID 22149576 in Expert review of gastroenterology & hepatology as Letter, Comment, with publication-date metadata of 2012-02 (month precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings. ([`pubmed-observation-pmid-22149576-2018-12-01-b2b7d1063c8d`](#source-pubmed-observation-pmid-22149576-2018-12-01-b2b7d1063c8d))

### Paragraph 1

PubMed lists PMID 22149576 in Expert review of gastroenterology & hepatology as Letter, Comment, with publication-date metadata of 2012-02 (month precision). PeptideScanner associated the retained record with the identity slug linaclotide. These fields reproduce attributed bibliographic metadata and do not summarize or endorse the article's findings. ([`pubmed-observation-pmid-22149576-2018-12-01-b2b7d1063c8d`](#source-pubmed-observation-pmid-22149576-2018-12-01-b2b7d1063c8d))

### Paragraph 2

This page reproduces bounded bibliographic metadata attributed to PubMed. Its title and publication details are source metadata, not PeptideScanner's endorsement or an assertion of safety, efficacy, or scientific truth. ([`pubmed-observation-pmid-22149576-2018-12-01-b2b7d1063c8d`](#source-pubmed-observation-pmid-22149576-2018-12-01-b2b7d1063c8d))

## Sources

<a id="source-pubmed-observation-pmid-22149576-2018-12-01-b2b7d1063c8d"></a>
- **Clarification of trial end points presented in a recent review of linaclotide. · retained source version 1:2018-12-01:current:b2b7d1063c8d1206b8c9f3f4a0b2cd9d40655bb667f0276366aa6ceecf498122** — PubMed; class A. [Open source](https://pubmed.ncbi.nlm.nih.gov/22149576/) (`pubmed-observation-pmid-22149576-2018-12-01-b2b7d1063c8d`)

## Correction lineage

No correction is recorded for this version.

## Reporting boundaries and unknowns

PeptideScanner reproduces bounded bibliographic metadata attributed to PubMed. It does not summarize or endorse the article's findings.

- Sources outside the selected public PeptideScanner bundle may exist and are not represented by this object.
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## Suggested citation

PeptideScanner. "Clarification of trial end points presented in a recent review of linaclotide." Version 1, published 2026-08-13. https://peptidescanner.com/evidence/v1/objects/pubmed-pmid-22149576-linaclotide-v1.json SHA-256: f36ffb473318e8c33fd18a6d5e9a07e199ead4a6fac1ff5c85c4e262c16f3d1a.